G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Drug development needs a new brand of science.
TL;DR: An interdisciplinary NIH centre points the way to break with the past to develop new medicines, says Garret FitzGerald, president of the National Institutes of Health.
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Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.
Jesus A. Ocana,Eric J. Romer,Ravi P. Sahu,Sven-Christian Pawelzik,Garret A. FitzGerald,Mark H. Kaplan,Jeffrey B. Travers +6 more
TL;DR: Results support the hypothesis that MC PAFR activation promotes the immunosuppressive effects of PAF in part through histamine- and PGE2-dependent mechanisms.
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Perestroika in pharma: evolution or revolution in drug development?
TL;DR: Developing a more modular approach to drug discovery and development will evolve, deriving some features from the not-for-profit sector, but this will require linked initiatives among academia, the pharmaceutical industry, the US National Institutes of Health, and the US Food and Drug Administration.
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Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.
Emanuela Ricciotti,Cecilia Castro,Soon Yew Tang,William T.E. Briggs,James A. West,Dania Malik,Seth D. Rhoades,Hu Meng,Xuanwen Li,Nicholas F. Lahens,Jeffrey A. Sparks,Elizabeth W. Karlson,Aalim M. Weljie,Julian L. Griffin,Garret A. FitzGerald +14 more
TL;DR: In this article, large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective p...
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Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.
TL;DR: In this paper, an indirect approach to estimating prostaglandins biosynthesis has been used to measure biologically inert but chemically stable metabolites using mass spectrometry, which has been remarkable how informative it has turned out to be.