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George Thireos

Researcher at Foundation for Research & Technology – Hellas

Publications -  30
Citations -  2580

George Thireos is an academic researcher from Foundation for Research & Technology – Hellas. The author has contributed to research in topics: Gene & Saccharomyces cerevisiae. The author has an hindex of 19, co-authored 30 publications receiving 2546 citations. Previous affiliations of George Thireos include Academy of Athens & University of Crete.

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The complete DNA sequence of yeast chromosome III.

Stephen G. Oliver, +146 more
- 07 May 1992 - 
TL;DR: The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined, which is the first complete sequence analysis of an entire chromosome from any organism.
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Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

TL;DR: GCN5 is a new member of the recently revealed general class of transcriptional regulators that collaborate with certain specific DNA binding activators to promote high levels of transcription.
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5' untranslated sequences are required for the translational control of a yeast regulatory gene

TL;DR: The complete nucleotide sequence of the GCN4 gene reveals the existence of an unusually long 5' untranslated region in the corresponding mRNA, which is defined as a region required for the translational regulation of theGCN4 mRNA.
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The Gcn5 bromodomain co-ordinates nucleosome remodelling

TL;DR: It is shown that bromodomain residues essential for acetyl-lysine binding are not required in vivo for Gcn5-mediated histone acetylation but are fundamental for the subsequent Swi2-dependent nucleosome remodelling and consequent transcriptional activation.
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Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.

TL;DR: The results show that the YAP1 protein has a pivotal role in the metabolic stress response and the acquisition of stress tolerance.