H
Herbert C. Morse
Researcher at National Institutes of Health
Publications - 400
Citations - 23200
Herbert C. Morse is an academic researcher from National Institutes of Health. The author has contributed to research in topics: B cell & Lymphoma. The author has an hindex of 77, co-authored 400 publications receiving 21998 citations. Previous affiliations of Herbert C. Morse include University of Southampton & Istituto Superiore di Sanità.
Papers
More filters
Journal ArticleDOI
A Critical Role for IL-21 in Regulating Immunoglobulin Production
Katsutoshi Ozaki,Rosanne Spolski,Carl G. Feng,Chen-Feng Qi,Jun Cheng,Alan Sher,Herbert C. Morse,Chengyu Liu,Pamela L. Schwartzberg,Warren J. Leonard +9 more
TL;DR: It is demonstrated that, although mice deficient in the receptor for IL-21 (IL-21R) have normal lymphoid development, after immunization, these animals have higher production of the immunoglobulin IgE, but lower IgG1, than wild-type animals, suggesting that these γc-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID.
Journal ArticleDOI
TRIM family proteins and their emerging roles in innate immunity
TL;DR: Recent data are described that reveal broader antiviral and antimicrobial activities of TRIM proteins and their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence is discussed.
Journal ArticleDOI
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
Katsutoshi Ozaki,Katsutoshi Ozaki,Rosanne Spolski,Rachel Ettinger,Hyoung F. Kim,Gang Wang,Chen Feng Qi,Patrick Hwu,Daniel J. Shaffer,Shreeram Akilesh,Derry C. Roopenian,Herbert C. Morse,Peter E. Lipsky,Warren J. Leonard +13 more
TL;DR: It is demonstrated that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells, explaining howIL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo.
Journal ArticleDOI
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
Thomas Holtschke,Jürgen Löhler,Yuka Kanno,Thomas Fehr,N.A. Giese,Frank Rosenbauer,Jing Lou,Klaus-Peter Knobeloch,Lucia Gabriele,Jeffrey F. Waring,Martin F. Bachmann,Rolf M. Zinkernagel,Herbert C. Morse,Keiko Ozato,Ivan Horak +14 more
TL;DR: A novel role for ICSBP is suggested in regulating the proliferation and differentiation of hematopoietic progenitor cells in mice with a null mutation of ICS BP.
Journal ArticleDOI
ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8α+ Dendritic Cells
Giovanna Schiavoni,Fabrizio Mattei,Paola Sestili,Paola Borghi,Massimo Venditti,Herbert C. Morse,Filippo Belardelli,Lucia Gabriele +7 more
TL;DR: ICSBP is a crucial factor in the regulation of two possibly linked processes: (a) the development and activity of mIPCs, whose lack in ICSBP−/− mice may explain their high susceptibility to virus infections; (b) the generation and activation of CD8α+ DCs, whose impairment in ICD mice can be responsible for the defective generation of a Th1 type of immune response.