2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
Tom Bowen,Marco Cicardi,Henriette Farkas,Konrad Bork,Hilary Longhurst,Bruce L. Zuraw,Emel Aygoeren‐Pürsün,Timothy J. Craig,Karen Binkley,Jacques Hébert,Bruce Ritchie,Laurence Bouillet,Stephen Betschel,Della Cogar,John M. Dean,Ramachand Devaraj,Azza Hamed,Palinder Kamra,Paul K. Keith,Gina Lacuesta,Eric Leith,Harriet Lyons,Sean R. Mace,Barbara Mako,Doris Neurath,Man-Chiu Poon,Georges-Etienne Rivard,R. Robert Schellenberg,Dereth Rowan,Anne Rowe,Donald Stark,Smeeksha Sur,Ellie Tsai,Richard Warrington,Susan Waserman,Rohan Ameratunga,Jonathan A. Bernstein,Janne Björkander,Kristylea Brosz,John Brosz,Anette Bygum,Teresa Caballero,Michael M. Frank,George Füst,George Harmat,Amin Kanani,Wolfhart Kreuz,Marcel Levi,Henry Li,Inmaculada Martinez-Saguer,Dumitru Moldovan,István Nagy,Erik Waage Nielsen,Patrik Nordenfelt,Avner Reshef,E. Rusicke,Sarah Smith-Foltz,Peter J. Späth,Lilian Varga,Zhi Yu Xiang +59 more
TLDR
Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches.Abstract:
C1 inhibitor deficiency (hereditary angioedema [HAE]) is a rare disorder for which there is a lack of consensus concerning diagnosis, therapy, and management, particularly in Canada. European initiatives have driven the approach to managing HAE with 3 C1-INH Deficiency Workshops held every 2 years in Hungary starting in 1999, with the third Workshop having recently been held in May 2003. The European Contact Board has established a European HAE Registry that will hopefully advance our knowledge of this disorder. The Canadian Hereditary Angioedema Society/Societe d'Angioedeme Hereditaire du Canada organized a Canadian International Consensus Conference held in Toronto, Ontario, Canada, on October 24 to 26, 2003, to foster consensus between major European and North American HAE treatment centers. Papers were presented by investigators from Europe and North America, and this consensus algorithm approach was discussed. There is a paucity of double-blind placebo-controlled trials in the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Enclosed is the consensus algorithm approach recommended for the diagnosis, therapy, and management of HAE and agreed to by the authors of this article. This document is only a consensus algorithm approach and requires validation. As such, participants agreed to make this a living 2003 algorithm (ie, a work in progress) and agreed to review its content at future international HAE meetings. The consensus, however, has strength in that it was arrived at by the meeting of patient-care providers along with patient group representatives and individual patients reviewing information available to date and reaching agreement on how to approach the diagnosis, therapy, and management of HAE circa 2003. Hopefully evidence to support approaches to the management of HAE will approach the level of meta-analysis of randomized controlled trials in the near future.read more
Citations
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Journal ArticleDOI
Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group
Marco Cicardi,Werner Aberer,Aleena Banerji,Murat Bas,Jonathan A. Bernstein,Konrad Bork,Teresa Caballero,Henriette Farkas,Anete Sevciovic Grumach,Allen P. Kaplan,Marc A. Riedl,Massimo Triggiani,Andrea Zanichelli,Bruce L. Zuraw +13 more
TL;DR: Four types of acquired and three types of hereditary angioedema were identified as separate forms from the analysis of the literature and were presented in detail at the meeting.
Journal ArticleDOI
The international WAO/EAACI guideline for the management of hereditary angioedema—The 2017 revision and update
Marcus Maurer,Markus Magerl,I. J. Ansotegui,Emel Aygören-Pürsün,Stephen Betschel,Konrad Bork,Tom Bowen,H. Balle Boysen,Henriette Farkas,Anete Sevciovic Grumach,Michihiro Hide,Constance H. Katelaris,R. Lockey,Hilary Longhurst,W. R. Lumry,Inmaculada Martinez-Saguer,Dumitru Moldovan,Alexander Nast,Ruby Pawankar,Paul Potter,Marc A. Riedl,Bruce Ritchie,Lanny J. Rosenwasser,Mario Sánchez-Borges,Yuxiang Zhi,Bruce L. Zuraw,Timothy J. Craig +26 more
TL;DR: The goal of this guideline update and revision is to provide clinicians and their patients with guidance that will assist them in making rational decisions in the management of H AE with deficient C1‐inhibitor (type 1) and HAE with dysfunctional C1-inhibitors (type 2).
Journal ArticleDOI
BSACI guidelines for the management of chronic urticaria and angio-oedema.
TL;DR: In this paper, a guideline for the management of patients with chronic urticaria and angio-oedema has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI).
Journal ArticleDOI
Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group
Marco Cicardi,Konrad Bork,Teresa Caballero,Timothy J. Craig,Huamin Henry Li,Hilary Longhurst,Avner Reshef,Bruce L. Zuraw +7 more
TL;DR: Evidence‐based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group.
Journal ArticleDOI
8. Hereditary angioedema.
TL;DR: Hereditary angioedema is an episodic swelling disorder with autosomal dominant inheritance that is caused by a mutation in one of the 2 copies of the gene for the plasma protein C1 inhibitor with the product of 1 gene unable to control generation of bradykinin.
References
More filters
Journal ArticleDOI
Randomized controlled trial of screening for hepatocellular carcinoma.
TL;DR: The finding indicated that biannual screening reduced HCC mortality by 37%.
Reference EntryDOI
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
David Henry,Paul A. Carless,Annette J Moxey,Dianne L. O'Connell,Barrie Stokes,Dean Fergusson,Katharine Ker +6 more
TL;DR: Data from the head-to-head trials suggest an advantage of aprotinin over the lysine analogues TXA and EACA in terms of reducing perioperative blood loss, but the differences were small.
Journal ArticleDOI
Angiotensin-Converting Enzyme Inhibitors
TL;DR: Ongoing studies will elucidate the effect of ACE inhibitor on cardiovascular mortality in essential hypertension, the role of ACE inhibitors in patients without ventricular dysfunction after myocardial infarction, and the roleof ACE inhibitors compared with newly available angiotensin AT1 receptor antagonists.
Journal ArticleDOI
A biochemical abnormality in herediatry angioneurotic edema: absence of serum inhibitor of c' 1-esterase.
TL;DR: Evidence suggests that absence of serum inhibitor of C′1-esterase is an inherited abnormality in those with the familial type of angioneurotic edema, and this determination may permit identification of young family members who will have attacks of swelling later in life.
Journal ArticleDOI
Tranexamic acid: a review of its use in surgery and other indications.
Christopher J. Dunn,Karen L. Goa +1 more
TL;DR: The drug reduces postoperative blood losses and transfusion requirements in a number of types of surgery, with potential cost and tolerability advantages over aprotinin, and appears to reduce rates of mortality and urgent surgery in patients with upper gastrointestinal haemorrhage.
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