H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
Papers
More filters
Journal ArticleDOI
Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia.
Jun Taguchi,Yasushi Miyazaki,Chizuko Tsutsumi,Yasushi Sawayama,Koji Ando,Hideki Tsushima,Takuya Fukushima,Tomoko Hata,Shinichiro Yoshida,Kazutaka Kuriyama,Sumihisa Honda,Itsuro Jinnai,Hiroyuki Mano,Masao Tomonaga +13 more
TL;DR: The level of the MPO gene in AC133 positive leukemia cells that would contain a putative AML stem/progenitor compartment was quantitatively measured and the difference in the survival of MPOg-H and MPOG-L was statistically meaningful, demonstrating the possible prognostic impact of the expression of MPo gene inAC133positive leukemia cells.
Journal ArticleDOI
Retroviral expression screening of oncogenes in pancreatic ductal carcinoma
Hiroyuki Kisanuki,Young Lim Choi,Tomoaki Wada,Ryozo Moriuchi,Shin-ichiro Fujiwara,Ruri Kaneda,Koji Koinuma,Madoka Ishikawa,Shuji Takada,Yoshihiro Yamashita,Hiroyuki Mano +10 more
TL;DR: A retroviral cDNA expression library from a PDC cell line was constructed and used to screen transforming genes in PDC, and a long terminal repeat-driven overexpression of ARAF1 mRNA was confirmed to induce transformed foci in fibroblasts.
Journal ArticleDOI
High-throughput screening of genome fragments bound to differentially acetylated histones.
Ruri Kaneda,Minoru Toyota,Yoshihiro Yamashita,Koji Koinuma,Young Lim Choi,Jun Ota,Hiroyuki Kisanuki,Madoka Ishikawa,Shuji Takada,Kazuyuki Shimada,Hiroyuki Mano +10 more
TL;DR: A genome‐wide screening method to isolate genome fragments embedded in histones subject to differential acetylation, and a number of cancer‐related genes were revealed to be the targets of HDAC in the cancer cells, including those for tumour protein 73 and cell division cycle 34.
Proceedings ArticleDOI
Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor -
Sadao Kuromitsu,Masamichi Mori,Itsuro Shimada,Yutaka Kondoh,Nobuaki Shindoh,Takatoshi Soga,Takashi Furutani,Satoshi Konagai,Hideki Sakagami,Mari Nakata,Yoko Ueno,Rika Saito,Masao Sasamata,Hiroyuki Mano,Masafumi Kudou +14 more
TL;DR: The results suggest that ASP3026 is a novel and selective ALK inhibitor, which is orally active, and will possibly target NSCLC patients possessing the EML4-ALK fusion.
Journal ArticleDOI
Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter
Nobuhiko Hasegawa,Ikuko Takeda Nakamura,Toshihide Ueno,Shinya Kojima,Masahito Kawazu,Keisuke Akaike,Taketo Okubo,Tatsuya Takagi,Yoshiyuki Suehara,Takuo Hayashi,Tsuyoshi Saito,Kazuo Kaneko,Hiroyuki Mano,Shinji Kohsaka +13 more
TL;DR: The microfluidic chip-type cell sorter On-chip Sort was used to construct a system for detecting circulating sarcoma cells (CSCs) and may allow CSCs to become an early predictor for metastasis and recurrence of Sarcoma.