H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy.
Yukiyo Ogata,Masafumi Takahashi,Koichi Takeuchi,Shuichi Ueno,Hiroyuki Mano,Shigeo Ookawara,Eiji Kobayashi,Uichi Ikeda,Kazuyuki Shimada +8 more
TL;DR: The findings suggest that fluvastatin induces apoptosis in cardiac myocytes via protein prenylation and the subsequent inhibition of Rho, and may play a role in the pathogenesis of cardiac hypertrophy and remodeling.
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High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project
Norihiro Kato,Toshiyuki Miyata,Yasuharu Tabara,Tomohiro Katsuya,Kazuyuki Yanai,Hironori Hanada,Kei Kamide,Jun Nakura,Katsuhiko Kohara,Fumihiko Takeuchi,Hiroyuki Mano,Michio Yasunami,Akinori Kimura,Yoshikuni Kita,Hirotsugu Ueshima,Tomohiro Nakayama,Masayoshi Soma,Akira Hata,Akihiro Fujioka,Yuhei Kawano,Kazuwa Nakao,Akihiro Sekine,Teruhiko Yoshida,Yusuke Nakamura,Takao Saruta,Toshio Ogihara,Sumio Sugano,Tetsuro Miki,Hitonobu Tomoike +28 more
TL;DR: A three-tiered, high-density association study of hypertension has nominated several susceptibility genes for hypertension, and independent replication will clarify their etiological relevance.
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Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase
Ken-ichi Ohya,Sachiko Kajigaya,Akira Kitanaka,Koji Yoshida,Akira Miyazato,Yoshihiro Yamashita,Takeo Yamanaka,Uichi Ikeda,Kazuyuki Shimada,Keiya Ozawa,Hiroyuki Mano +10 more
TL;DR: BRDG1 appears to function as a docking protein acting downstream of Tec in BCR signaling, and was shown to participate in a positive feedback loop by increasing the activity of Tec.
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Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.
Yasuhiko Kano,Miyuki Akutsu,Saburo Tsunoda,Tohru Izumi,Hiroyuki Kobayashi,Hiroyuki Mano,Yusuke Furukawa +6 more
TL;DR: The findings suggest that FK228 is a promising candidate for combining with most anticancer agents except for methotrexate and vincristine, which produce suboptimal effects.
Journal ArticleDOI
Reprogramming of human postmitotic neutrophils into macrophages by growth factors.
Hiroto Araki,Naoyuki Katayama,Yoshihiro Yamashita,Hiroyuki Mano,Atsushi Fujieda,Eiji Usui,Hidetsugu Mitani,Kohshi Ohishi,Kazuhiro Nishii,Masahiro Masuya,Nobuyuki Minami,Tsutomu Nobori,Hiroshi Shiku +12 more
TL;DR: The data show that in response to cytokines, postmitotic neutrophils can become macrophages, which may represent another differentiation pathway toward macrophage in human postnatal hematopoiesis.