Hiroyuki Mano

TL;DR: The present findings suggest that the simultaneous administration of STI571 with other agents except methotrexate would be advantageous for cytotoxic effects against Ph(+) leukemias and these combinations would be worthy of clinical trials.

TL;DR: This work discovered novel microRNA candidates using two approaches: testing of computationally predicted microRNAs by a modified microarray-based detection system and cloning and sequencing of large numbers of small RNAs from different human and mouse tissues.

TL;DR: KLC1-ALK is the first novel oncogenic fusion identified using only FFPE tissues, and this finding will broaden the potential value of archival FFPe tissues and provide further biological and clinical insights into ALK-positive lung cancer.

TL;DR: The data have shown a unique profile of gene mutations in human leukemia, and a somatic change responsible for an Arg-to-His substitution at amino-acid position 882 of DNA methyltransferase 3A, which resulted in a loss ofDNA methylation activity of >50%.

TL;DR: The presence of this abortive processing machinery and diversity of MCPIP1-related genes may imply a dynamic evolutional transition of the RNA silencing system, and suggest that the balance between processing and destroying ribonucleases modulates miRNA biogenesis and potentially affects pathological miRNA dysregulation.