H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Journal ArticleDOI
DNA microarray analysis of in vivo progression mechanism of heart failure.
Shuichi Ueno,Ruri Ohki,Toru Hashimoto,Toshihiro Takizawa,Koichi Takeuchi,Yoshihiro Yamashita,Jun Ota,Young Lim Choi,Tomoaki Wada,Koji Koinuma,Keiji Yamamoto,Uichi Ikeda,Kazuyuki Shimada,Hiroyuki Mano +13 more
TL;DR: Interestingly, expression of the gene for the D-binding protein, an apoptotic-related transcriptional factor, became decreased upon the transition to heart failure, the first report to describe the transcriptome of cardiac myocytes during the disease progression of heart failure.
Journal ArticleDOI
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells
Keiko Ito,Yasuji Ueda,Masaki Kokubun,Masashi Urabe,Toshiya Inaba,Hiroyuki Mano,Hirofumi Hamada,Toshio Kitamura,Hideaki Mizoguchi,Sakata Tsuneaki,Mamoru Hasegawa,Keiya Ozawa +11 more
TL;DR: It is speculated that when the selective amplifier genes are expressed in the primitive hematopoietic stem cells, the growth signal predominates and that the population of transduced stem cells expands upon estrogen treatment, even if some of the cells enter the differentiation pathway.
Journal ArticleDOI
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing.
Hidenori Kage,Shinji Kohsaka,Aya Shinozaki-Ushiku,Yoshihisa Hiraishi,Jiro Sato,Kazuhiro Nagayama,Tetsuo Ushiku,Daiya Takai,Jun Nakajima,Kiyoshi Miyagawa,Hiroyuki Aburatani,Hiroyuki Mano,Takahide Nagase +12 more
TL;DR: CTNB, EBUS‐TBNA and TBB mostly resulted in adequate DNA and RNA quality and enabled high‐quality targeted NGS analysis, and this work confirmed that small biopsies using these methods are preferable to resection to make a pathological diagnosis.
Journal ArticleDOI
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.
Joji Nagasaki,Takashi Inozume,Nicolas Sax,Ryo Ariyasu,Masakazu Ishikawa,Kazuo Yamashita,Masahito Kawazu,Toshihide Ueno,Takuma Irie,Etsuko Tanji,Takao Morinaga,Akiko Honobe,Takehiro Ohnuma,Mitsuru Yoshino,Takekazu Iwata,Katsushige Kawase,Keita Sasaki,Toyoyuki Hanazawa,Vitaly Kochin,Tatsuyoshi Kawamura,Hiroyuki Matsue,Masayuki Hino,Hiroyuki Mano,Yutaka Suzuki,Hiroyoshi Nishikawa,Yosuke Togashi +25 more
TL;DR: In this paper , a single-cell sequencing was used to show that TILs include skewed T cell clonotypes characterized by exhaustion (Tex) or nonexhaustion signatures (Tnon-ex).
Journal Article
Tec protein-tyrosine kinase directly associates with lyn protein-tyrosine kinase through its n-terminal unique domain
TL;DR: This is the first report demonstrating the direct association between distinct cytoplasmic protein-tyrosine kinases, especially through N-terminal unique domain, in a mouse IL-3-dependent myeloid cell line.