H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
Papers
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Journal ArticleDOI
Molecular pathology quality control in Southeast Asia: Results of a multiregional quality assurance study from MASTER KEY Asia
Hitomi Sumiyoshi Okuma,Hiroshi Yoshida,Yoshihisa Kobayashi,Motoko Arakaki,Chiharu Mizoguchi,Lina Inagaki,V. Pei Jye,Adam Malik Bin Ismail,Hwoei Fen Soo Hoo,Suhana Yusak,Marcelo Severino B Imasa,Thinh Nguyen Huy,Tu Thai Anh,Shinji Kohsaka,Hiroyuki Mano,Kan Yonemori,Kenichi Nakamura,Yasushi Yatabe +17 more
TL;DR: In this paper , a questionnaire surveying preanalytical procedures (Part I) was administered, quality assessment of immunohistochemistry (IHC) staining and DNA/RNA extracted from the representative FFPE specimens from each hospital (Part II) was conducted, and the quality of DNA and RNA extracted from formalin-fixed paraffinembedded (FFPE) specimens for genomic sequencing (Part III) was examined.
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Secondary EML4-ALK-positive lung adenocarcinoma in a patient previously treated for acute lymphoblastic leukemia in childhood: a case report.
Yoichi Nakamura,Hirokazu Taniguchi,Kosuke Mizoguchi,Takaya Ikeda,Kohei Motoshima,Hiroyuki Yamaguchi,Seiji Nagashima,Katsumi Nakatomi,Manabu Soda,Hiroyuki Mano,Shigeru Kohno +10 more
TL;DR: It was concluded that this echinoderm microtubule-associated protein-like 4 gene-anaplastic lymphoma kinase gene-positive lung adenocarcinoma was a secondary epithelial malignancy.
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Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
Takamasa Ishino,Shusuke Kawashima,Etsuko Tanji,Toshihide Ueno,Youki Ueda,Sadahisa Ogasawara,Kazuhito Sato,Hiroyuki Mano,Soichiro Ishihara,Naoya Kato,Masahito Kawazu,Yosuke Togashi +11 more
TL;DR: In this paper , the authors evaluated 88 high-frequency microsatellite instability (MSI-H) colorectal cancers and analyzed the function of the identified neoantigenic mutations and their influence on programmed cell death 1 (PD-1) blockade efficacy.
Patent
Tec tyrosine kinase promoter
TL;DR: In this paper, a DNA having promoter activity of Tec tyrosine kinase and a vector having incorporated within it the promoter to enable a high level expression of an exogenous gene in hematopoietic stem cells and hepatic cells.
Journal ArticleDOI
Identification of Activated RRAS2 in Tongue Carcinoma Cell Line
Hideki Watanabe,Yoshihiro Yamashita,Shuji Takada,Young Lim Choi,Shin-ichiro Fujiwara,Manabu Soda,Munehiro Enomoto,Kentaro Kurashina,Hisashi Hatanaka,Mikio Kusama,Hiroyuki Mano +10 more
TL;DR: These findings, which are the first to demonstrate the activating mutation at this codon ofRRAS2, may help to better understand the role of RRAS2 in human carcinogenesis.