H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Journal ArticleDOI
Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells
Tadaaki Yamada,Shinji Takeuchi,Junya Nakade,Kenji Kita,Takayuki Nakagawa,Shigeki Nanjo,Takahiro Nakamura,Kunio Matsumoto,Manabu Soda,Hiroyuki Mano,Toshimitsu Uenaka,Seiji Yano +11 more
TL;DR: Paracrine receptor activation by ligand from the microenvironment may trigger resistance to ALK inhibitors in EML4-ALK lung cancer cells, suggesting that receptor ligands from micro environment may be additional targets during treatment with ALK inhibition.
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Transforming mutations of RAC guanosine triphosphatases in human cancers
Masahito Kawazu,Toshihide Ueno,Kenji Kontani,Yoshitaka Ogita,Mizuo Ando,Kazutaka Fukumura,Azusa Yamato,Manabu Soda,Kengo Takeuchi,Yoshio Miki,Hiroyuki Yamaguchi,Takahiko Yasuda,Takahiko Yasuda,Tomoki Naoe,Yoshihiro Yamashita,Toshiaki Katada,Young Lim Choi,Hiroyuki Mano,Hiroyuki Mano +18 more
TL;DR: It is shown that the human sarcoma cell line HT1080 harbors both NRAS(Q61K) and RAC1(N92I) mutant proteins, which are potential targets for the development of new therapeutic agents.
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Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13
TL;DR: The evidence indicates that Tec kinases are involved in Gα12/13‐induced, Rho‐mediated activation of SRF, which is sensitive to C3, suggesting the involvement of Rho.
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Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Masafumi Seki,Shunsuke Kimura,Shunsuke Kimura,Tomoya Isobe,Kenichi Yoshida,Hiroo Ueno,Yaeko Nakajima-Takagi,Changshan Wang,Lin Lin,Ayana Kon,Hiromichi Suzuki,Yusuke Shiozawa,Keisuke Kataoka,Yoichi Fujii,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Teppei Shimamura,Kyoko Masuda,Hiroshi Kawamoto,Kentaro Ohki,Motohiro Kato,Yuki Arakawa,Katsuyoshi Koh,Ryoji Hanada,Hiroshi Moritake,Masaharu Akiyama,Ryoji Kobayashi,Takao Deguchi,Yoshiko Hashii,Toshihiko Imamura,Atsushi Sato,Nobutaka Kiyokawa,Akira Oka,Yasuhide Hayashi,Masatoshi Takagi,Atsushi Manabe,Akira Ohara,Keizo Horibe,Masashi Sanada,Atsushi Iwama,Hiroyuki Mano,Satoru Miyano,Seishi Ogawa,Junko Takita +44 more
TL;DR: Comprehensive profiling of 121 cases of pediatric T-ALL using transcriptome and/or targeted capture sequencing is reported, through which new recurrent gene fusions involving SPI1 are identified (STMN1-SPI1 and TCF7- SPI1).
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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
Shogo Kumagai,Yosuke Togashi,Chika Sakai,Akihito Kawazoe,Masahito Kawazu,Toshihide Ueno,Eiichi Sato,Takeshi Kuwata,Takahiro Kinoshita,Masami Yamamoto,Sachiyo Nomura,Tetsuya Tsukamoto,Hiroyuki Mano,Kohei Shitara,Hiroyoshi Nishikawa +14 more
TL;DR: It is proposed that the metabolic advantage conferred by RHOA mutations enables Treg cell accumulation within GC tumors, generating an immunosuppressive TME that underlies resistance to ICB.