H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
Papers
More filters
Journal ArticleDOI
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer
Ikuko Takeda Nakamura,Shinji Kohsaka,Masachika Ikegami,Hiroshi Ikeuchi,Toshihide Ueno,Kunhua Li,Tyler S. Beyett,Takafumi Koyama,Toshio Shimizu,Noboru Yamamoto,Fumiyuki Takahashi,Kazuhisa Takahashi,Michael J. Eck,Hiroyuki Mano +13 more
TL;DR: It is revealed that recurrent compound mutations within FGFRs affect the transforming potential and TKI-sensitivity of corresponding kinases, which reveals the necessity to develop next-generation FGFR inhibitors, which are effective against all oncogenic FGFR variants.
Journal ArticleDOI
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment
Shusuke Kawashima,Takashi Inozume,Takashi Inozume,Masahito Kawazu,Toshihide Ueno,Joji Nagasaki,Etsuko Tanji,Akiko Honobe,Takehiro Ohnuma,Takehiro Ohnuma,Tatsuyoshi Kawamura,Yoshiyasu Umeda,Yasuhiro Nakamura,Tomonori Kawasaki,Yukiko Kiniwa,Osamu Yamasaki,Satoshi Fukushima,Yuzuru Ikehara,Hiroyuki Mano,Yutaka Suzuki,Hiroyoshi Nishikawa,Hiroyuki Matsue,Togashi Yosuke +22 more
TL;DR: In this article, the authors established four pairs of autologous tumor cell lines and tumor-infiltrating lymphocytes (TILs) from patients with melanoma treated with ICIs.
Journal ArticleDOI
Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter
Koji Koinuma,Ruri Kaneda,Minoru Toyota,Yoshihiro Yamashita,Shuji Takada,Young Lim Choi,Tomoaki Wada,Masaki Okada,Fumio Konishi,Hideo Nagai,Hiroyuki Mano +10 more
TL;DR: Using methylated CpG island amplification coupled with representational difference analysis (MCA-RDA), genomic fragments that are selectively methylated in CRCs positive for MLH1 methylation are screened, resulting in the identification of hundreds of C pG islands containing genomic fragments.
Journal ArticleDOI
DNA microarray analysis of T cell-type lymphoproliferative disease of granular lymphocytes
Hideki Makishima,Fumihiro Ishida,Toshiro Ito,Kiyoshi Kitano,Shuichi Ueno,Ken Ohmine,Yoshihiro Yamashita,Jun Ota,Masao Ota,Kazuyoshi Yamauchi,Hiroyuki Mano +10 more
TL;DR: Microarray analysis with a purified T‐cell subset is an efficient approach to investigate the pathological condition of Tcell‐type LDGL, and expression of the gene for interleukin 1β was specific to LDGL T cells, which was further confirmed by the examination of the serum level of IL‐1β protein.
Journal ArticleDOI
STK10 missense mutations associated with anti-apoptotic function.
Kazutaka Fukumura,Yoshihiro Yamashita,Masahito Kawazu,Eirin Sai,Fujiwara Si,Naoya Nakamura,Kengo Takeuchi,Mizuo Ando,Kohei Miyazono,Toshihide Ueno,Keiya Ozawa,Hiroyuki Mano +11 more
TL;DR: The results suggest that STK 10 functions as a tumor suppressor gene, and that dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.