Hiroyuki Mano

TL;DR: Adult T-cell leukemia/lymphoma (ATLL) is a neoplasia characterized by the massive invasion of various organs by tumor cells and expression of the gene for c-Met, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was specific to the acute type among 41 patients with ATLL by microarray.

TL;DR: This is the first report that demonstrates expression of the GM-CSF gene in solid tumors at the mRNA level, and it is believed that this gene is involved in granulocyte-macrophage colony-stimulating factor-related cancers.

TL;DR: DNA micro-array analysis reveals that each stage of MDS has its own ‘molecular signature’, indicating the feasibility of differential diagnosis of M DS based on gene expression profile and demonstrating that the current clinical diagnosis ofMDS results in the misclassification of patients with regard to these molecular signatures.

TL;DR: Several transcriptomic features, including CMS classification and related genes, were associated with response to PD-1 blockade in MSI-H/dMMR GI tumors, which can help develop predictive biomarkers or combination immunotherapies.

TL;DR: It is revealed that the CRC integrates the pre-B-cell receptor (BCR) and lipid metabolism to maintain itself and govern malignant phenotypes, opening therapeutic avenues to indirectly target fusion-driven leukemia by disrupting its CRC.