Hiroyuki Mano

TL;DR: Results show that Dicer is essential during early retinal development, using retina-specific conditional knockout of Dicer in mice for survival, proliferation, and differentiation.

TL;DR: It is shown that CDC25C mutations are frequently found in FPD/AML patients and is a novel gene target identified in haematological malignancies, useful as a clinical biomarker that predicts progression of FPD-AML in the early stage.

TL;DR: The present study demonstrates that human monocytic cells respond to mechanical deformation with induction of immediate-early and inflammatory genes, and suggests that mechanical stress in vivo, such as that associated with hypertension, may play an important part in atherogenesis and instability of coronary artery plaques, through biomechanical effects on vascular macrophages.

TL;DR: This is the first genetic study indicating an association between the CIAS1 gene and susceptibility to essential hypertension (EH), and it is proposed here the CIas1 is associated with EH through the dominant expression of transcripts, which may depend on theCIAS1-VNTR genotype.

TL;DR: 5′-terminal diversity of the tec messages is investigated to demonstrate a predominant form of the Tec protein in mouse hematopoietic cell lines and it is concluded that Tec is involved in the signaling pathway of IL-3.