H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Journal ArticleDOI
Ex vivo expansion of human CD8 + T cells using autologous CD4 + T cell help
Marcus O. Butler,Osamu Imataki,Osamu Imataki,Yoshihiro Yamashita,Makito Tanaka,Makito Tanaka,Sascha Ansén,Sascha Ansén,Alla Berezovskaya,Genita Metzler,Matthew I. Milstein,Mary M. Mooney,Andrew P. Murray,Hiroyuki Mano,Hiroyuki Mano,Lee M. Nadler,Lee M. Nadler,Naoto Hirano +17 more
TL;DR: It is suggested that human CD4+ T cell help can be leveraged to expand CD8+ T cells in vitro, and an in vitro model that advances the understanding of the immunobiology of human CD3 monoclonal antibody OKT3 as well as other immune accessory molecules is developed.
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ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity.
Hideki Kimura,Takahiro Nakajima,Kengo Takeuchi,Manabu Soda,Hiroyuki Mano,Toshihiko Iizasa,Yukiko Matsui,Mitsuru Yoshino,Masato Shingyoji,Meiji Itakura,Makiko Itami,Dai Ikebe,Sana Yokoi,Hajime Kageyama,Miki Ohira,Akira Nakagawara +15 more
TL;DR: The ALK inhibitor presented in this study is effective in EML4-ALK NSCLC cases and advanced disease with this fusion gene was correlated with younger generation, and almost all the multiple bone and lymph node metastases quickly disappeared.
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Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1.
Koji Yoshida,Yoshihiro Yamashita,Akira Miyazato,Ken-ichi Ohya,Akira Kitanaka,Uichi Ikeda,Kazuyuki Shimada,Takeo Yamanaka,Keiya Ozawa,Hiroyuki Mano +9 more
TL;DR: The results suggest that Tec is an important mediator of signaling from the BCR to Dok-1, and this effect required both the Tec homology and Src homology 2 domains of Tec in addition to its kinase activity.
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β2-Microglobulin Identified as an Apoptosis-Inducing Factor and Its Characterization
Masaki Mori,Yasuhito Terui,Masayuki Ikeda,Hiroshi Tomizuka,Masaya Uwai,Tadashi Kasahara,Nobuyuki Kubota,Takehito Itoh,Yuji Mishima,Miyuki Douzono-Tanaka,Muneo Yamada,Seiichi Shimamura,Jiro Kikuchi,Yusuke Furukawa,Yukihito Ishizaka,Kazuma Ikeda,Hiroyuki Mano,Keiya Ozawa,Kiyohiko Hatake +18 more
TL;DR: It is demonstrated that β2m plays a previously unrecognized and important role in regulating the elimination of tumor cells, which occurs as a result of the action ofβ2m as an apoptosis-inducing factor.
Journal ArticleDOI
Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening.
Hisashi Hatanaka,Mamiko Tsukui,Shuji Takada,Kentaro Kurashina,Young Lim Choi,Manabu Soda,Yoshihiro Yamashita,Hidenori Haruta,Toru Hamada,Toshihide Ueno,Kiichi Tamada,Yoshinori Hosoya,Naohiro Sata,Yoshikazu Yasuda,Hideo Nagai,Kentaro Sugano,Hiroyuki Mano +16 more
TL;DR: Data here implicate FFAR2 in carcinogenesis of the digestive tract for the first time, with the use of a retroviral cDNA expression library constructed from a surgically resected clinical specimen of GBC.