H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Journal ArticleDOI
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects
Osamu Hashizume,Sakiko Ohnishi,Takayuki Mito,Akinori Shimizu,Kaori Ishikawa,Kazuto Nakada,Manabu Soda,Hiroyuki Mano,Sumie Togayachi,Hiroyuki Miyoshi,Keisuke Okita,Jun-Ichi Hayashi +11 more
TL;DR: It is shown that reprogramming of elderly fibroblasts restores age-associated mitochondrial respiration defects, indicating that these aging phenotypes are reversible and are similar to differentiation phenotypes in that both are controlled by epigenetic regulation, not by mutations in either the nuclear or the mitochondrial genome.
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Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation.
Tetsuya Yamada,Hideki Katagiri,Yasushi Ishigaki,Takehide Ogihara,Junta Imai,Kenji Uno,Yutaka Hasegawa,Junhong Gao,Hisamitsu Ishihara,Akira Niijima,Hiroyuki Mano,Hiroyuki Aburatani,Tomoichiro Asano,Yoshitomo Oka +13 more
TL;DR: It is shown that ectopic expression of very low levels of uncoupling protein 1 in epididymal fat (Epi) reverses both insulin and leptin resistance, and afferent-nerve signals from intra-abdominal fat tissue regulate food intake by modulating hypothalamic leptin sensitivity.
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Mouse microRNA profiles determined with a new and sensitive cloning method
Shuji Takada,Eugene Berezikov,Yoshihiro Yamashita,Mariana Lagos-Quintana,Wigard P. Kloosterman,Munehiro Enomoto,Hisashi Hatanaka,Fujiwara Si,Hideki Watanabe,Manabu Soda,Young Lim Choi,Ronald H.A. Plasterk,Edwin Cuppen,Hiroyuki Mano +13 more
TL;DR: The data indicate that the total number of miRNAs in vertebrates is larger than previously appreciated and that the expression of these molecules is tightly controlled in a tissue- and developmental stage-specific manner.
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Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes.
Masafumi Takahashi,Jun Nishihira,Masahisa Shimpo,Yuka Mizue,Shuichi Ueno,Hiroyuki Mano,Eiji Kobayashi,Uichi Ikeda,Kazuyuki Shimada +8 more
TL;DR: The present results suggest that MIF is expressed by the myocardium in response to redox stress and may play a role in the pathogenesis of myocardial ischemia.
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Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.
TL;DR: It is demonstrated here that Tec, a cytoplasmic, src-related kinase, physically associates with c-kit through a region that contains a proline-rich motif, amino terminal of the SH3 domain, which may account for the synergy seen in the actions of SCF and IL-3 on hematopoietic stem cells.