Hiroyuki Mano

TL;DR: TFF‐1 is not only a biomarker, but also a potential molecular target for non‐TRU‐type lung adenocarcinomas with gastrointestinal features, and the knockdown of Tff‐1 inhibited cell proliferation and soft‐agar colony formation and induced apoptosis in a TFF‐ 1‐high and KRAS‐mutated lung adeccarcinoma cell line.

TL;DR: Global profiling of gene expression in AML blasts has the potential both to identify a small number of genes whose expression is associated with clinical outcome and to provide insight into the molecular pathogenesis of this condition.

TL;DR: It is found that genistein, a tyrosine kinase inhibitor, augmented IL-1α-dependent NF-κB activation, suggesting the presence of a tyosine kinases mediating a suppression signal on NF- κB, and suggests the possibility that tyrosin kinase negatively regulates NF-σB.

TL;DR: Gene expression imbalances were measured for tyrosine kinase (TK) genes using Nanostring in 19 samples of inflammatory myofibroblastic tumor (IMT) in cases were immunohistochemically stained with anaplastic lymphoma kinase and pan-tropomyosin-related-kinase (pan-Trk) antibodies.

TL;DR: MuSTA as discussed by the authors is a pipeline for multi-sample long-read transcriptome assembly, which enables construction of a transcriptome from long read sequence data using the constructed transcriptome as a reference, using RNA extracted from 22 clinical breast cancer specimens.