H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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The Tyr-Kinase Inhibitor AG879, That Blocks the ETK-PAK1 Interaction, Suppresses the RAS-Induced PAK1 Activation and Malignant
Hong S. He,Yumiko Hirokawa,Aviv Gazit,Yoshihiro Yamashita,Hiroyuki Mano,Yuko Kawakami,Ching Yi Hsieh,Hsing Jien Kung,Guillaume Lessene,Jonathan B. Baell,Alexander Levitzki,Hiroshi Maruta +11 more
TL;DR: It is demonstrated that AG 879 even at 10 nM blocks the specific interaction between the Tyr-kinase ETK and PAK1 (a CDC42/ Rac-dependent Ser/Thr kinase) in cell culture, suggesting that this drug blocks the ETK-PAK1 pathway by targeting a highly sensitive kinase upstream of ETK.
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Cells with stem‐like properties are associated with the development of HPV18‐positive cervical cancer
Misako Kusakabe,Ayumi Taguchi,Michihiro Tanikawa,Ryota Wagatsuma,Miki Yamazaki,Saki Tsuchimochi,Yusuke Toyohara,Akira Kawata,Satoshi Baba,Toshihide Ueno,Kenbun Sone,Mayuyo Mori-Uchino,Masako Ikemura,Hiroko Matsunaga,Takeshi Nagamatsu,Osamu Wada-Hiraike,Masahito Kawazu,Tetsuo Ushiku,Haruko Takeyama,Katsutoshi Oda,Kei Kawana,Hiroyuki Mano,Yutaka Osuga +22 more
TL;DR: In this article , the cellular origins of cervical cancer and the histological differentiation of human papillomavirus (HPV)infected cells were inferred using phylogenetic analysis and by assessing the HPV integration sites.
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Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary?
Hiroaki Aizawa,Takahiro Karasaki,Kazuhiro Nagayama,Aya Shinozaki-Ushiku,Hiroyuki Aburatani,Hiroyuki Mano,Jun Nakajima +6 more
TL;DR: An 80-year-old man with a history of cutaneous squamous cell carcinoma (SCC) was referred to the department for a solitary lung nodule and the lung lesion was diagnosed as primary lung SCC, as the two tumors possessed distinct somatic mutations in TP53.
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A Japanese nationwide network for the diagnosis of EML4-ALK-positive lung cancer: A joint study of ALCAS and NEJ004.
Manabu Soda,Akira Inoue,Kazutoshi Isobe,Hitoshi Miyazawa,Tomoaki Tanaka,Kengo Takeuchi,Yuichi Ishikawa,Kiyoko Kobayashi,Koichi Hagiwara,Hiroyuki Mano +9 more
TL;DR: A practical scheme to diagnose in clinics EML4-ALK–positive NSCLC is developed, and a Japanese nation- wide diagnostic network for EML 4-ALK is started as a collaborative project between ALK Lung Cancer Study Group (ALCAS) and North East Japan Gefitinib Study group (NEJ).