H
Hiroyuki Mano
Researcher at University of Tokyo
Publications - 308
Citations - 24554
Hiroyuki Mano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 66, co-authored 275 publications receiving 22190 citations. Previous affiliations of Hiroyuki Mano include Astellas Pharma & Nagasaki University.
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Journal ArticleDOI
Incidentally Proven Pulmonary "ALKoma"
Atsushi Osoegawa,Kaname Nosaki,Hitoshi Miyamoto,Takuro Kometani,Fumihiko Hirai,Kaoru Ondo,Takashi Seto,Kenji Sugio,Young Lim Choi,Manabu Soda,Hiroyuki Mano,Yukito Ichinose +11 more
TL;DR: The commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion, and the commercial-based ALK FISH is useful for screening pulmonary ALKoma.
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Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro
Yasuhiko Kano,Masaru Tanaka,Miyuki Akutsu,Kiyoshi Mori,Yasuo Yazawa,Hiroyuki Mano,Yusuke Furukawa +6 more
TL;DR: Sequential administration of pemetrexed followed by docetaxel may provide the greatest anti-tumor effects for this combination in the treatment of lung cancer.
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Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.
Kentaro Susaki,Akira Kitanaka,Hiroaki Dobashi,Yoshitsugu Kubota,Katsuharu Kittaka,Tomohiro Kameda,Genji Yamaoka,Hiroyuki Mano,Keichiro Mihara,Toshihiko Ishida +9 more
TL;DR: The role of Tec PTK is investigated using the Jurkat T-lymphoid cell line stably transfected with a cDNA encoding Tec to conclude that this PTK mediates signals that negatively regulate CD25 expression induced by TCR cross-linking, which implies that thisPTK plays a role in the attenuation of IL-2 activity in human T-LYmphocytes.
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Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant.
Aya Shinozaki-Ushiku,Shinji Kohsaka,Hidenori Kage,Katsutoshi Oda,Kiyoshi Miyagawa,Jun Nakajima,Hiroyuki Aburatani,Hiroyuki Mano,Tetsuo Ushiku +8 more
TL;DR: Multiple BAP1‐deficient cancers that developed in a single patient suggest the newly identified germline variant of B AP1 gene to be pathogenic and this case expands the clinical spectrum of BAP 1‐tumor predisposition syndrome.
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Identification of the transforming activity of Indian hedgehog by retroviral expression screening
Hisashi Hatanaka,Shuji Takada,Mamiko Tsukui,Young Lim Choi,Kentaro Kurashina,Manabu Soda,Yoshihiro Yamashita,Hidenori Haruta,Toru Hamada,Kiichi Tamada,Yoshinori Hosoya,Naohiro Sata,Hideo Nagai,Yoshikazu Yasuda,Kentaro Sugano,Hiroyuki Mano +15 more
TL;DR: Quantitation of I HH mRNA among clinical specimens has revealed that the expression level of IHH in BTC with APBDJ is higher than that in BTC without APBD J and than in non‐cancerous biliary tissues, implicate a direct role of IHC in the carcinogenesis of BTC withAPBDJ.