H
Huck-Hui Ng
Researcher at Genome Institute of Singapore
Publications - 144
Citations - 35090
Huck-Hui Ng is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 67, co-authored 138 publications receiving 32616 citations. Previous affiliations of Huck-Hui Ng include Agency for Science, Technology and Research & National University of Singapore.
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Journal ArticleDOI
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Xinsheng Nan,Huck-Hui Ng,Colin A. Johnson,Carol D. Laherty,Bryan M. Turner,Robert N. Eisenman,Adrian Bird +6 more
TL;DR: The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2, an abundant nuclear protein that is essential for mouse embryogenesis.
Journal ArticleDOI
Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
Xi Chen,Han Xu,Ping Yuan,Fang Fang,Fang Fang,Mikael Huss,Vinsensius B. Vega,Eleanor Wong,Yuriy L. Orlov,Weiwei Zhang,Weiwei Zhang,Jianming Jiang,Jianming Jiang,Yuin-Han Loh,Yuin-Han Loh,Hock Chuan Yeo,Zhen Xuan Yeo,Vipin Narang,Kunde R Govindarajan,Bernard Leong,Atif Shahab,Yijun Ruan,Guillaume Bourque,Wing-Kin Sung,Neil D. Clarke,Chia-Lin Wei,Huck-Hui Ng,Huck-Hui Ng +27 more
TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
Journal ArticleDOI
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Yuin-Han Loh,Qiang Wu,Joon Lin Chew,Joon Lin Chew,Vinsensius B. Vega,Weiwei Zhang,Weiwei Zhang,Xi Chen,Xi Chen,Guillaume Bourque,Joshy George,Bernard Leong,Jun Liu,Kee Yew Wong,Ken W. Sung,Charlie W.H. Lee,Xiao Dong Zhao,Kuo Ping Chiu,Leonard Lipovich,Vladimir A. Kuznetsov,Paul Robson,Paul Robson,Lawrence W. Stanton,Chia-Lin Wei,Yijun Ruan,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +28 more
TL;DR: By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating.
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A global map of p53 transcription-factor binding sites in the human genome.
Chia-Lin Wei,Qiang Wu,Vinsensius B. Vega,Kuo Ping Chiu,Patrick Ng,Tao Zhang,Atif Shahab,How Choong Yong,Yutao Fu,Zhiping Weng,Jianjun Liu,Xiao Dong Zhao,Joon-Lin Chew,Joon-Lin Chew,Yen Ling Lee,Vladimir A. Kuznetsov,Wing-Kin Sung,Lance D. Miller,Bing Lim,Bing Lim,Edison T. Liu,Qiang Yu,Huck-Hui Ng,Huck-Hui Ng,Yijun Ruan +24 more
TL;DR: A robust approach is described that couples chromatin immunoprecipitation (ChIP) with the paired-end ditag (PET) sequencing strategy for unbiased and precise global localization of transcription-factor binding sites (TFBS).
Journal ArticleDOI
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
TL;DR: A novel polypeptide highly related to the metastasis-associated protein 1, MTA2, and the methyl-CpG-binding domain-containing protein, MBD3, were found to be subunits of the NuRD complex, which may provide a means of gene silencing by DNA methylation.