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In-Hyun Park
Researcher at Yale University
Publications - 137
Citations - 22758
In-Hyun Park is an academic researcher from Yale University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 57, co-authored 127 publications receiving 20714 citations. Previous affiliations of In-Hyun Park include Boston Children's Hospital & Brigham and Women's Hospital.
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Reprogramming of human somatic cells to pluripotency with defined factors
In-Hyun Park,In-Hyun Park,Rui Zhao,Rui Zhao,Jason A. West,Jason A. West,Akiko Yabuuchi,Akiko Yabuuchi,Hongguang Huo,Hongguang Huo,Tan A. Ince,Paul H. Lerou,M. William Lensch,M. William Lensch,George Q. Daley,George Q. Daley +15 more
TL;DR: The data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture.
Journal ArticleDOI
Disease-Specific Induced Pluripotent Stem Cells
In-Hyun Park,Natasha Arora,Hongguang Huo,Nimet Maherali,Tim Ahfeldt,Tim Ahfeldt,Akiko Shimamura,M. William Lensch,M. William Lensch,Chad A. Cowan,Konrad Hochedlinger,George Q. Daley +11 more
TL;DR: The generation of induced pluripotent stem cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance are described, offering an unprecedented opportunity to recapitulate both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development.
Journal ArticleDOI
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.
Akiko Doi,In-Hyun Park,Bo Wen,Peter Murakami,Martin J. Aryee,Rafael A. Irizarry,Brian R. Herb,Christine Ladd-Acosta,Junsung Rho,Sabine Loewer,Justine D. Miller,Thorsten M. Schlaeger,George Q. Daley,Andrew P. Feinberg +13 more
TL;DR: Substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine island shores in nine human iPS cell lines as compared to their parental fibroblasts are found, suggesting two mechanisms for epigenetic reprogramming in iPS cells and cancer.
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Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.
Madeleine Ball,Jin Billy Li,Yuan Gao,Je-Hyuk Lee,Emily M LeProust,In-Hyun Park,Bin Xie,George Q. Daley,George M. Church +8 more
TL;DR: Two complementary approaches that use next-generation sequencing technology to detect cytosine methylation are introduced and it is confirmed that gene-body methylation in highly expressed genes is a consistent phenomenon throughout the human genome.
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Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: In this paper, the authors characterized the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identified numerous lincRNA whose expression is linked to pluripotency.