Thomas Gevaert

TL;DR: Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.

TL;DR: In this paper, a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, was proposed.

TL;DR: It is shown that the development of cystitis-induced bladder dysfunction is strongly impaired in Trpv4−/− mice, and HC-067047 is described, a previously uncharacterized, potent, and selective TRPV4 antagonist that increases functional bladder capacity and reduces micturition frequency in WT mice and rats with Cystitis.

TL;DR: Evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function is provided and a previously unrecognized role for TRpV4 in voiding behavior is demonstrated, raising the possibility that TRPV 4 plays acritical role in urothelium-mediated transduction of intravesical mechanical pressure.

TL;DR: This review attempts to summarize the existing knowledge about TRP channels in the urogenital tract and indicates a growing conviction that disturbances in afferent (sensory) mechanisms are highly important in the pathogenesis of functional problems and the TRP family forms an interesting new target to focus on.