J
Jean-Christophe Lagier
Researcher at Aix-Marseille University
Publications - 311
Citations - 17625
Jean-Christophe Lagier is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Genome & Medicine. The author has an hindex of 50, co-authored 274 publications receiving 13861 citations. Previous affiliations of Jean-Christophe Lagier include Institut de recherche pour le développement & Centre national de la recherche scientifique.
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Journal ArticleDOI
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,M. Mailhe,Barbara Doudier,Johan Courjon,Valérie Giordanengo,Vera Esteves Vieira,Hervé Tissot Dupont,Stéphane Honoré,Philippe Colson,Eric Chabrière,Bernard La Scola,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +17 more
TL;DR: Hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin, which was significantly more efficient for virus elimination.
Journal ArticleDOI
Microbial culturomics: paradigm shift in the human gut microbiome study
Jean-Christophe Lagier,Fabrice Armougom,Matthieu Million,Perrine Hugon,Isabelle Pagnier,Catherine Robert,Fadi Bittar,Ghislain Fournous,Gregory Gimenez,Marie Maraninchi,Jean-François Trape,Eugene V. Koonin,B. La Scola,Didier Raoult +13 more
TL;DR: Culturomics complements metagenomics by overcoming the depth bias inherent in metagenomic approaches, and identifies 174 species never described previously in the human gut.
Journal ArticleDOI
Chloroquine and Hydroxychloroquine as Available Weapons to Fight COVID-19
Philippe Colson,Jean-Marc Rolain,Jean-Christophe Lagier,Philippe Brouqui,Didier Raoult,Didier Raoult +5 more
TL;DR: The Covid-19 pandemic triggered, more frequently, anxiety, depression, stress and post-traumatic stress disorders in the general population and health professionals Women, students and nurses are among the most affected.
Journal ArticleDOI
Culture of previously uncultured members of the human gut microbiota by culturomics
Jean-Christophe Lagier,Saber Khelaifia,Maryam Tidjani Alou,S. Ndongo,Niokhor Dione,Perrine Hugon,Aurelia Caputo,Frédéric Cadoret,Sory Ibrahima Traore,El hadji Seck,Grégory Dubourg,Guillaume André Durand,Gaël Mourembou,E. Guilhot,Amadou Hamidou Togo,Sara Bellali,Dipankar Bachar,Nadim Cassir,Fadi Bittar,Jeremy Delerce,M. Mailhe,D. Ricaboni,Melhem Bilen,Nicole Prisca Makaya Dangui Nieko,Ndeye Mery Dia Badiane,Camille Valles,Donia Mouelhi,Khoudia Diop,Matthieu Million,Didier Musso,Jônatas Santos Abrahão,Esam I. Azhar,Fehmida Bibi,Muhammad Yasir,Aldiouma Diallo,Cheikh Sokhna,Félix Djossou,Véronique Vitton,Catherine Robert,Jean-Marc Rolain,Bernard La Scola,Pierre-Edouard Fournier,Anthony Levasseur,Didier Raoult +43 more
TL;DR: It is shown that the use of culturomics allows the culture of organisms corresponding to sequences previously not assigned, which doubles the number of species isolated at least once from the human gut.
Journal ArticleDOI
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,Jacques Sevestre,Morgane Mailhe,Barbara Doudier,Camille Aubry,Sophie Amrane,Piseth Seng,Marie Hocquart,Carole Eldin,Julie Finance,Vera Esteves Vieira,Hervé Tissot-Dupont,Stéphane Honoré,Andreas Stein,Matthieu Million,Philippe Colson,Bernard La Scola,Véronique Veit,Alexis Jacquier,Jean Claude Deharo,Michel Drancourt,Pierre-Edouard Fournier,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +28 more
TL;DR: There is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease.