J
Jean-Vianney Haure-Mirande
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 25
Citations - 1098
Jean-Vianney Haure-Mirande is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: TREM2 & Biology. The author has an hindex of 8, co-authored 18 publications receiving 634 citations.
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Journal ArticleDOI
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.
Benjamin Readhead,Jean-Vianney Haure-Mirande,Cory C. Funk,Matthew A. Richards,Paul Shannon,Vahram Haroutunian,Vahram Haroutunian,Mary Sano,Mary Sano,Winnie S. Liang,Noam D. Beckmann,Nathan D. Price,Eric M. Reiman,Eric E. Schadt,Michelle E. Ehrlich,Sam Gandy,Joel T. Dudley +16 more
TL;DR: This study constructs multiscale networks of the late-onset AD-associated virome, and elucidates networks linking molecular, clinical, and neuropathological features with viral activity and indicates viral activity constituting a general feature of AD.
Journal ArticleDOI
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Ying-Wooi Wan,Ying-Wooi Wan,Rami Al-Ouran,Rami Al-Ouran,Carl Grant Mangleburg,Carl Grant Mangleburg,Thanneer M. Perumal,Tom V. Lee,Tom V. Lee,Katherine Allison,Katherine Allison,Vivek Swarup,Cory C. Funk,Chris Gaiteri,Mariet Allen,Minghui Wang,Sarah M. Neuner,Catherine C. Kaczorowski,Vivek M. Philip,Gareth R. Howell,Heidi Martini-Stoica,Hui Zheng,Hongkang Mei,Xiaoyan Zhong,Jungwoo Wren Kim,Valina L. Dawson,Ted M. Dawson,Ping-Chieh Pao,Ping-Chieh Pao,Li-Huei Tsai,Li-Huei Tsai,Jean-Vianney Haure-Mirande,Michelle E. Ehrlich,Paramita Chakrabarty,Yona Levites,Xue Wang,Eric B. Dammer,Gyan Srivastava,Sumit Mukherjee,Solveig K. Sieberts,Larsson Omberg,Kristen D. Dang,James A. Eddy,Phil Snyder,Yooree Chae,Sandeep Amberkar,Sandeep Amberkar,Wenbin Wei,Wenbin Wei,Winston Hide,Winston Hide,Christoph Preuss,Ayla Ergun,Phillip J. Ebert,David C. Airey,Sara Mostafavi,Lei Yu,Hans-Ulrich Klein,Hans-Ulrich Klein,Gregory W. Carter,David A. Collier,Todd E. Golde,Allan I. Levey,David A. Bennett,Karol Estrada,T. Matthew Townsend,Bin Zhang,Eric E. Schadt,Philip L. De Jager,Philip L. De Jager,Nathan D. Price,Nilufer Ertekin-Taner,Zhandong Liu,Zhandong Liu,Joshua M. Shulman,Lara M. Mangravite,Benjamin A. Logsdon +76 more
TL;DR: A consensus atlas of the human brain transcriptome in Alzheimer’s disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples, is presented, highlighting transcriptional networks altered by human brain pathophysiology and identifying correspondences with mouse models for AD preclinical studies.
Journal ArticleDOI
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Noam D. Beckmann,Wei-Jye Lin,Minghui Wang,Ariella Cohain,Alexander W. Charney,Pei Wang,Weiping Ma,Ying-Chih Wang,Cheng Jiang,Mickael Audrain,Phillip H. Comella,Amanda K. Fakira,Siddharth P. Hariharan,Gillian M. Belbin,Kiran Girdhar,Allan I. Levey,Nicholas T. Seyfried,Eric B. Dammer,Duc M. Duong,James J. Lah,Jean-Vianney Haure-Mirande,Ben Shackleton,Tomas Fanutza,Robert D. Blitzer,Eimear E. Kenny,Jun Zhu,Vahram Haroutunian,Pavel Katsel,Pavel Katsel,Sam Gandy,Sam Gandy,Zhidong Tu,Michelle E. Ehrlich,Bin Zhang,Stephen R.J. Salton,Eric E. Schadt +35 more
TL;DR: A causal role for VGF in protecting against AD pathogenesis and progression is supported, with extensive validation in the 5xFAD mouse model.
Journal ArticleDOI
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Jean-Vianney Haure-Mirande,Mickael Audrain,Tomas Fanutza,Soong Ho Kim,William L. Klein,Charles G. Glabe,Ben Readhead,Joel T. Dudley,Robert D. Blitzer,Minghui Wang,Bin Zhang,Eric E. Schadt,Sam Gandy,Michelle E. Ehrlich +13 more
TL;DR: Reduction of TYROBP gene expression and/or protein levels could represent an immune-inflammatory therapeutic opportunity for modulating early stage LOAD, potentially leading to slowing or arresting the progression to full-blown clinical and pathological LOAD.
Journal ArticleDOI
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Jean-Vianney Haure-Mirande,Minghui Wang,Mickael Audrain,Tomas Fanutza,Soong Ho Kim,Szilvia Heja,Ben Readhead,Joel T. Dudley,Robert D. Blitzer,Eric E. Schadt,Eric E. Schadt,Bin Zhang,Sam Gandy,Michelle E. Ehrlich +13 more
TL;DR: It is established that the network pathology observed in postmortem human LOAD brain can be faithfully recapitulated in the brain of a genetically manipulated mouse and suggested that TYROBP/DAP12 could represent a novel therapeutic target to slow, arrest, or prevent the development of sporadic LOAD.