J
Jelle De Medts
Researcher at Ghent University
Publications - 9
Citations - 445
Jelle De Medts is an academic researcher from Ghent University. The author has contributed to research in topics: Notch signaling pathway & T cell. The author has an hindex of 8, co-authored 8 publications receiving 365 citations. Previous affiliations of Jelle De Medts include Ghent University Hospital.
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Journal ArticleDOI
cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)
Mathieu J.M. Bertrand,Saskia Lippens,An Staes,Barbara Gilbert,Ria Roelandt,Jelle De Medts,Kris Gevaert,Wim Declercq,Peter Vandenabeele +8 more
TL;DR: This study found that XIAP, cI AP1 and cIAP2 not only directly bind to RIP1 and RIP2 but also to RIP3 and RIP4, and identified Lys51 and Lys145 of RIP4 as two critical residues for cIIAP1-mediated ubiquitination and NF-κB activation.
Journal ArticleDOI
Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
Inge Van de Walle,Els Waegemans,Jelle De Medts,Greet De Smet,Magda De Smedt,Sylvia Snauwaert,Bart Vandekerckhove,Tessa Kerre,Georges Leclercq,Jean Plum,Thomas Gridley,Tao Wang,Ute Koch,Freddy Radtke,Tom Taghon +14 more
TL;DR: Jagged2 preferentially signals through Notch3 to promote γδ T cell development, which in turn influences T cell proliferation and cell reprograming.
Journal ArticleDOI
Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern
Seppe Vander Beken,Juma'a R. Al Dulayymi,Thomas Naessens,Gani Koza,Max Maza-Iglesias,Richard Rowles,Cornelia Theunissen,Jelle De Medts,Ellen A. Lanckacker,Mark S. Baird,Johan Grooten +10 more
TL;DR: The differential innate immune activities of MAs demonstrated here, dependent on oxygenation class and cis versus α‐methyl‐trans cyclopropane chemistry, identify a novel means for M. tuberculosis to steer host immune responses during infection.
Journal ArticleDOI
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Steven Goossens,Enrico Radaelli,Odile Blanchet,Kaat Durinck,Joni Van der Meulen,Sofie Peirs,Tom Taghon,Cedric S. Tremblay,Magdaline Costa,Morvarid Farhang Ghahremani,Jelle De Medts,Sonia Bartunkova,Katharina Haigh,Claire Schwab,Natalie Farla,Tim Pieters,Filip Matthijssens,Nadine Van Roy,J Adam Best,Kim Deswarte,Pieter Bogaert,Catherine Carmichael,Adam Samuel Rickard,Santi Suryani,Lauryn S. Bracken,Raed Alserihi,Kirsten Canté-Barrett,Lieven Haenebalcke,Emmanuelle Clappier,Pieter Rondou,Karolina Slowicka,Danny Huylebroeck,Ananda W. Goldrath,Viktor Janzen,Matthew P. McCormack,Richard B. Lock,David J. Curtis,Christine J. Harrison,Geert Berx,Frank Speleman,Jules P.P. Meijerink,Jean Soulier,Pieter Van Vlierberghe,Jody J. Haigh +43 more
TL;DR: The zinc finger E-box-binding transcription factor ZEB2 is revealed as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using the Zeb2-driven mouse model.
Journal ArticleDOI
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.
Inge Van de Walle,Anne-Catherine Dolens,Kaat Durinck,Katrien De Mulder,Wouter Van Loocke,Sagar S. Damle,Els Waegemans,Jelle De Medts,Imke Velghe,Magda De Smedt,Bart Vandekerckhove,Tessa Kerre,Jean Plum,Georges Leclercq,Ellen V. Rothenberg,Pieter Van Vlierberghe,Frank Speleman,Tom Taghon +17 more
TL;DR: It is shown that GATA3, in contrast to TCF1, controls human T-cell lineage commitment through direct regulation of three distinct processes: repression of NK-cell fate, upregulation of T- cell lineage genes to promote further differentiation and restraint of Notch activity.