Jennifer H. Mansfield

TL;DR: Using transgenes to drive Cre expression in discrete regions of the limb mesoderm, it is found that removal of Dicer results in the loss of processed miRNAs, and Dicer is required for the formation of normal mouse limbs.

TL;DR: A technique for visualizing detailed miRNA expression patterns in mouse embryos is reported, elucidate the tissue-specific expression of several miRNAs during embryogenesis, and negatively regulates Hoxb8 and miR-196a, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex.

TL;DR: The data indicate that miR-196 functions in a fail-safe mechanism to assure the fidelity of expression domains that are primarily regulated at the transcriptional level, supporting the idea that many vertebrate miRNAs may function as a secondary level of gene regulation.

TL;DR: The sequence and annotation of the M. sexta genome, and a survey of gene expression in various tissues and developmental stages, provide an important new resource from a well-studied model insect species and will facilitate further biochemical and mechanistic experimental studies of many biological systems in insects.

TL;DR: It is proposed that exuperantia (exu) is a core component of a large protein complex involved in localizing mRNAs both within nurse cells and the developing oocyte.