J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
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Journal ArticleDOI
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes.
Peter Simmonds,Jens Bukh,Christophe Combet,Gilbert Deléage,Nobuyuki Enomoto,Stephen M. Feinstone,Phillippe Halfon,Geneviève Inchauspé,Carla Kuiken,Geert Maertens,Masashi Mizokami,Donald G. Murphy,Hiroaki Okamoto,Jean-Michel Pawlotsky,François Penin,Erwin Sablon,Tadasu Shin-I,Lieven Stuyver,Heinz-Jürgen Thiel,Sergei Viazov,Amy J. Weiner,Anders Widell +21 more
TL;DR: These proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future.
Journal ArticleDOI
Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource
D B Smith,Jens Bukh,Carla Kuiken,A. Scott Muerhoff,Charles M. Rice,Jack T. Stapleton,Peter Simmonds +6 more
TL;DR: This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013.
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Genomic analysis of the host response to hepatitis C virus infection.
Andrew I. Su,John Paul Pezacki,Lisa Wodicka,Amy D. Brideau,Lubica Supekova,Robert Thimme,Stefan Wieland,Jens Bukh,Robert H. Purcell,Peter G. Schultz,Francis V. Chisari +10 more
TL;DR: Gene expression analysis of liver biopsies in acutely infected chimpanzees reveals genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection.
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Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes
TL;DR: It is revealed that HCV exists as multiple, distinct genotypes, and phylogenetic analyses of complete and partial nucleotide sequences from isolates that represent all published variants of HCV revealed that the genetic relatedness among some of the genotypes was not equivalent in the different gene regions.
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Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Robert Thimme,Jens Bukh,Hans Christian Spangenberg,Stefan Wieland,Janell Pemberton,Carola Steiger,Sugantha Govindarajan,Robert H. Purcell,Francis V. Chisari +8 more
TL;DR: The results indicate that HCV spread outpaces the T cell response and thatHCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN -γ-producing T cells in the liver; and that it may not require the destruction of infected cells.