Jiahao Gao

TL;DR: In this article, the authors compared DNA input and mock IP and found that mock IPs contain only nonspecific interactions, and the sites predicted from them using DNA input indicate the spurious-site abundance.

TL;DR: In this paper, the authors constructed phased, diploid genomes for four cadaveric donors (using long-read sequencing) and systematically charted noncoding regulatory elements and transcriptional activity across more than 25 tissues from these donors.

TL;DR: This investigation provided an indispensable reference for ulteriorly exploring the role of AS events in the tumor microenvironment and immunotherapy efficiency, and rendered personalized prognosis monitoring for bladder cancer.

TL;DR: A method to use both controls in combination to further improve binding site detection is developed, demonstrating that using a DNA input control results in a definable set of spurious sites, and their abundance is tightly associated with the intrinsic properties of the ChIP-seq sample.

TL;DR: The EN-TEx dataset as mentioned in this paper contains 1,635 open-access datasets from four donors (∼30 tissues × ∼15 assays) mapped to matched, diploid genomes with long read phasing and structural variants, instantiating a catalog of >1 million allele-specific loci.