Jianhua Xing

TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.

TL;DR: Experimental and computational analyses identify multiple cell populations during the epithelial-to-mesenchymal transition and provide experimental confirmation for a model of cascading switches in phenotypes associated with TGF-β1–induced EMT of MCF10A cells that involves two double-negative feedback loops.

TL;DR: Three major signal transduction pathways that promote or regulate EMT in carcinoma are focused on, and systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery are highlighted.

TL;DR: A mathematical model is constructed for the core regulatory network controlling TGF-β-induced EMT and provides a mechanistic explanation on multiple experimental observations, showing that EMT is a sequential two-step program in which an epithelial cell first is converted to partial EMT then to the mesenchymal state, depending on the strength and duration of T GF-β stimulation.

Abstract: Recent simulation studies for four dipole-polarizable and for two fluctuating-charge water force fields have demonstrated that none of the force fields studied is capable of yielding a satisfactory description of the vapor−liquid coexistence curve from room temperature to the critical region. The performance of these polarizable force fields can be improved dramatically by introducing an additional coupling between the Lennard−Jones interaction parameters for a pair of oxygen sites and their partial charges (electronic configuration). Two different types of water models are presented which are based on either the three-site simple point charge (SPC) or the four-site transferable intermolecular potential 4 point (TIP4P) water representations. Adiabatic nuclear and electronic sampling Monte Carlo (ANES-MC) simulations in the Gibbs, isobaric−isothermal, and canonical ensembles were performed to calculate vapor−liquid coexistence curves, to determine the temperatures of maximum liquid density, and to evaluate...