Joy T. Boyer

TL;DR: The Genotype-Tissue Expression (GTEx) project is described, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

TL;DR: The landscape of gene expression across tissues is described, thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants are cataloged, complex network relationships are described, and signals from genome-wide association studies explained by eQTLs are identified.

TL;DR: In this article, the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues, and different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on principal component analysis.

TL;DR: The program's influence is likely to grow as ELSi research, genomics research, and policy development activities become increasingly integrated, and the benefits of increased integration while preserving the autonomy, objectivity, and intellectual independence of ELSI investigators presents ongoing challenges and new opportunities.

TL;DR: The evolution and goals of the ELSI program at NHGRI are summarized, the program's current research priorities are outlined, examples of activities within each priority area are provided, and a look to the future is provided, including the initiation of a strategic planning process.