J
Jun Sung Park
Researcher at Wellcome Trust Sanger Institute
Publications - 4
Citations - 179
Jun Sung Park is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Regulation of gene expression & Expression quantitative trait loci. The author has an hindex of 3, co-authored 4 publications receiving 58 citations. Previous affiliations of Jun Sung Park include European Bioinformatics Institute.
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Journal ArticleDOI
A map of transcriptional heterogeneity and regulatory variation in human microglia.
Adam Young,Adam Young,Natsuhiko Kumasaka,Fiona Calvert,Timothy R. Hammond,Timothy R. Hammond,Andrew J Knights,Nikolaos Panousis,Jun Sung Park,Jeremy Schwartzentruber,Jimmy Z. Liu,Kousik Kundu,Michael Segel,Natalia A. Murphy,Christopher E McMurran,Harry Bulstrode,Jason Correia,Karol P. Budohoski,Alexis J Joannides,Mathew R. Guilfoyle,Rikin A. Trivedi,Ramez W. Kirollos,Robert H. Morris,Matthew R. Garnett,Ivan Timofeev,Ibrahim Jalloh,Katherine Holland,Richard Mannion,Richard Mair,Colin Watts,Stephen J. Price,Peter J. Kirkpatrick,Thomas Santarius,Edward Mountjoy,Maya Ghoussaini,Nicole Soranzo,Omer Ali Bayraktar,Beth Stevens,Beth Stevens,Peter J. Hutchinson,Robin J.M. Franklin,Daniel J. Gaffney +41 more
TL;DR: In this paper, gene expression variation in primary human microglia isolated from 141 patients undergoing neurosurgery was profiled using expression quantitative trait loci (eQTL) mapping.
Posted ContentDOI
Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics
Vitalii Kleshchevnikov,Artem Shmatko,Artem Shmatko,Emma Dann,Alexander Aivazidis,Hamish W King,Hamish W King,Tong Li,Artem Lomakin,Veronika R. Kedlian,Mika Sarkin Jain,Mika Sarkin Jain,Jun Sung Park,Jun Sung Park,Lauma Ramona,Elizabeth Tuck,Anna Arutyunyan,Roser Vento-Tormo,Moritz Gerstung,Louisa K. James,Oliver Stegle,Oliver Stegle,Omer Ali Bayraktar +22 more
TL;DR: It is shown how сell2location can serve as a versatile first-line analysis tool to map tissue architectures in a high-throughput manner and its utility by mapping two complex tissues is demonstrated.
Posted ContentDOI
Spatial genomics maps the structure, character and evolution of cancer clones
Lomakin A,Lomakin A,Svedlund J,Svedlund J,Carina Strell,Carina Strell,Milana Gataric,Artem Shmatko,Artem Shmatko,Artem Shmatko,Jun Sung Park,Jun Sung Park,Young Seok Ju,Stefan C. Dentro,Stefan C. Dentro,Kleshchevnikov,Vaskivskyi,Tong Li,Omer Ali Bayraktar,Luiza Moore,S. Pinder,Andrea L. Richardson,Peter J. Campbell,Moritz Gerstung,Mats Nilsson,Lucy R. Yates +25 more
TL;DR: In this paper, the authors developed base specific in situ sequencing (BaSISS) to detect transcripts harboring clone-defining mutations, converted into quantitative clone maps and characterised through multi-layered data integration.
Posted ContentDOI
PoSTcode: Probabilistic image-based spatial transcriptomics decoder
Milana Gataric,Jun Sung Park,Jun Sung Park,Tong Li,Vasyl Vaskivskyi,Jessica Svedlund,Carina Strell,Carina Strell,Kenny Roberts,Mats Nilsson,Lucy R. Yates,Omer Ali Bayraktar,Moritz Gerstung +12 more
TL;DR: In this article, a re-parametrised matrix-variate Gaussian mixture model was proposed to account for correlated noise across fluorescence channels and imaging cycles, which is shown to recover up to 50% more confidently decoded molecules while simultaneously decreasing transcript mislabeling.