Maurizio Marconi

TL;DR: A meta-analysis from two independent OCD consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls, concludes that the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD.

TL;DR: A key role for lincRNA in T lymphocyte differentiation is demonstrated and a long-distance interaction between the genomic regions of the gene encoding linc-MAF-4 and MAF is identified, which suggested that l inc-MAf-4 regulated MAF transcription through the recruitment of chromatin modifiers.

TL;DR: Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation, and the hypothesis that there may be a causal genetic variation at this locus is supported.

TL;DR: To further characterize the genetic basis of primary biliary cirrhosis (PBC), genotyped patients and unaffected controls using a single nucleotide polymorphism array (Immunochip) enriched for autoimmune disease risk loci and identified a novel disease-associated locus near the TNFSF11 gene at 13q14.

TL;DR: The GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders.