Kaoru Fukami-Kobayashi

TL;DR: The H-InvDB as discussed by the authors is a database of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level.

TL;DR: In this article, a phylogenetic tree for the PBP family was constructed based on their amino acid sequences and three-dimensional structures, respectively, and it was shown that the proteins of each type clearly cluster together, strongly indicating that the change in the core structure occurred only once in the evolution of PBPs.

TL;DR: The DNA Data Bank of Japan (DDBJ) has made an effort to collect as much data as possible mainly from Japanese researchers, and developed the Genome Information Broker (GIB) and HGS, a database of the human genome, which have been updated incorporating newly available data and retrieval tools.

TL;DR: This result, together with the phylogenetic relationship, demonstrates that the repressors and the PBPs individually acquired the same ligand specificity by homoplasious replacement, even though their genes are encoded in the same operon.

TL;DR: The charge compensatory signal is more evident when it is sought by examining individual branches in the tree between reconstructed ancestral sequences at nodes in theTree, and it is found that the signal is especially strong when the positions pairs are in a single secondary structural unit, and may be useful in secondary structure prediction.