K
Karolina Edlund
Researcher at Technical University of Dortmund
Publications - 32
Citations - 1387
Karolina Edlund is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 20, co-authored 32 publications receiving 1079 citations.
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Journal ArticleDOI
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
Cristina Cadenas,Leonie van de Sandt,Karolina Edlund,Miriam Lohr,Birte Hellwig,Rosemarie Marchan,Marcus Schmidt,Jörg Rahnenführer,Henrik Oster,Jan G. Hengstler +9 more
TL;DR: Co Coordinated co-expression of clock genes, indicative of a functional circadian clock, is maintained in ER+, HER2-, low grade and non-metastasizing tumors but is compromised in more aggressive carcinomas.
Journal ArticleDOI
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
Patricio Godoy,Patricio Godoy,Wolfgang Schmidt-Heck,Karthick Natarajan,Baltasar Lucendo-Villarin,Dagmara Szkolnicka,Annika Asplund,Petter Björquist,Agata Widera,Regina Stöber,G Campos,Seddik Hammad,Agapios Sachinidis,Umesh Chaudhari,Georg Damm,Thomas S. Weiss,Andreas K. Nussler,Jane Synnergren,Karolina Edlund,Barbara Küppers-Munther,David C. Hay,Jan G. Hengstler +21 more
TL;DR: In this article, the authors performed a transcriptomic study with HLC derived from human embryonic and induced stem cells (ESC, hiPSC) from three different laboratories and identified gene networks representing successful and failed hepatocyte differentiation.
Journal ArticleDOI
Toxicogenomics directory of chemically exposed human hepatocytes.
Marianna Grinberg,Regina Stöber,Karolina Edlund,Eugen Rempel,Patricio Godoy,Raymond Reif,Agata Widera,Katrin Madjar,Wolfgang Schmidt-Heck,Rosemarie Marchan,Agapios Sachinidis,Dimitry Spitkovsky,Jürgen Hescheler,Helena Carmo,Marcelo Dutra Arbo,Bob van de Water,Steven Wink,Mathieu Vinken,Vera Rogiers,Sylvia Escher,Barry Hardy,Dragana Mitic,Glenn J. Myatt,Tanja Waldmann,Adil Mardinoglu,Georg Damm,Daniel Seehofer,Andreas K. Nussler,Thomas S. Weiss,Axel Oberemm,Alfons Lampen,Mirjam M. Schaap,Mirjam Luijten,Harry van Steeg,Wolfgang E. Thasler,Jos C. S. Kleinjans,Rob H. Stierum,Marcel Leist,Jörg Rahnenführer,Jan G. Hengstler +39 more
TL;DR: The introduced toxicotranscriptomics directory offers a basis for a rationale choice of candidate genes for biomarker evaluation studies and represents an easy to use source of background information on chemically influenced genes.
Journal ArticleDOI
Profiling cancer testis antigens in non–small-cell lung cancer
Dijana Djureinovic,Björn M. Hallström,Masafumi Horie,Johanna Sofia Margareta Mattsson,Linnea La Fleur,Linn Fagerberg,Hans Brunnström,Cecilia Lindskog,Katrin Madjar,Jörg Rahnenführer,Simon Ekman,Elisabeth Ståhle,Hirsh Koyi,Eva Brandén,Karolina Edlund,Jan G. Hengstler,Mats Lambe,Akira Saito,Johan Botling,Fredrik Pontén,Mathias Uhlén,Patrick Micke +21 more
TL;DR: The proposed prognostic impact of CTAs in lung cancer was not confirmed, neither in the RNAseq cohort nor in an independent meta-analysis of 1,117 NSCLC cases, so a set of 90 reliable CTAs is defined, including information on protein expression, methylation, and survival association.
Journal ArticleDOI
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Patricio Godoy,Agata Widera,Wolfgang Schmidt-Heck,G Campos,Christoph Meyer,Cristina Cadenas,Raymond Reif,Regina Stöber,Seddik Hammad,Seddik Hammad,Seddik Hammad,Larissa Pütter,Kathrin Gianmoena,Rosemarie Marchan,Ahmed Ghallab,Ahmed Ghallab,Karolina Edlund,Andreas K. Nussler,Wolfgang E. Thasler,Georg Damm,Daniel Seehofer,Thomas S. Weiss,Olaf Dirsch,Uta Dahmen,Rolf Gebhardt,Umesh Chaudhari,Kesavan Meganathan,Agapios Sachinidis,Jens M. Kelm,Ute Hofmann,René P. Zahedi,Reinhard Guthke,Nils Blüthgen,Steven Dooley,Jan G. Hengstler +34 more
TL;DR: It is shown that gene regulatory network alterations of cultivated hepatocytes resemble those of inflammatory liver diseases and should therefore be considered and exploited as disease models.