Axel Oberemm

TL;DR: The introduced toxicotranscriptomics directory offers a basis for a rationale choice of candidate genes for biomarker evaluation studies and represents an easy to use source of background information on chemically influenced genes.

TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.

TL;DR: It is hoped that toxicogenomic information can also contribute to the understanding and interpretation of effects seen with low dose exposure, and a better understanding of genomic expression will enable a greater insight into the factors behind the observed variability in susceptibility to chemical exposure.

TL;DR: The regression coefficients clearly indicated that the presence of arginine, phenylalanine, leucine and proline tend to enhance the desorption/ionization process which results in higher MALDI-MS peak intensities.

TL;DR: Previously observed in vitro/in vivo discrepancy can be explained by different pharmacokinetics present in vitro and in vivo, when the in vivo half-life is short and levels of some initially altered genes may have returned to control levels already 24 h after administration.