Cristina Cadenas

TL;DR: The history of the AOP concept and its most prominent strengths are discussed, including the advantages of a formalized approach, the systematic collection of weight of evidence, the linkage of mechanisms to apical end points, the examination of the plausibility of epidemiological data, the identification of critical knowledge gaps and the design of mechanistic test methods.

TL;DR: IGKC was consistently associated with metastasis-free survival across different molecular subtypes in node-negative breast cancer and predicted response to anthracycline-based neoadjuvant chemotherapy and was prognostic in NSCLC and colorectal cancer.

TL;DR: Co Coordinated co-expression of clock genes, indicative of a functional circadian clock, is maintained in ER+, HER2-, low grade and non-metastasizing tumors but is compromised in more aggressive carcinomas.

TL;DR: Investigating the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer using immunohistochemistry on a tissue microarray found IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup.

TL;DR: A novel segmentation-based method, TEPIC, is reported to predict TF binding by combining sets of OCRs with position weight matrices, and finds low affinity binding sites to improve the ability to explain gene expression variability compared to the standard presence/absence classification of binding sites.