Katherine S. Elliott

TL;DR: Common variants in the FER gene and associated molecular pathways are potential novel targets for therapy or prevention and candidates for the development of biomarkers for risk stratification.

TL;DR: The results indicate that the detectable genetic variation associated with extreme overweight is very similar to that previously found for general BMI, which suggests that population-based study designs with enriched sampling of individuals with the extreme phenotype may be an efficient method for identifying common variants that influence quantitative traits.

TL;DR: None of the association signals the authors identified reach genome-wide levels of statistical significance, therefore stressing the need for corroboration in sample sets of a larger size, and identifying loci conferring susceptibility to osteoarthritis will require large-scale sample sizes and well-defined phenotypes to minimise heterogeneity.

TL;DR: Two strikingly dichotomous HLA-associations are described, most significantly in Hla-DRB1*07:01 for LGI1, and HLA/CASPR2*11:001 for CASPR2.

TL;DR: Variation in PSARL sequence and/or expression may be an important new risk factor for type 2 diabetes and other components of the metabolic syndrome.