K
Kathleen Lake
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 14
Citations - 2098
Kathleen Lake is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Fatty liver. The author has an hindex of 10, co-authored 13 publications receiving 1217 citations. Previous affiliations of Kathleen Lake include University of Cincinnati.
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Journal ArticleDOI
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
Jason Lloyd-Price,Jason Lloyd-Price,Cesar Arze,Ashwin N. Ananthakrishnan,Melanie Schirmer,Melanie Schirmer,Julian Avila-Pacheco,Tiffany W. Poon,Elizabeth Andrews,Nadim J. Ajami,Kevin S. Bonham,Kevin S. Bonham,Colin J. Brislawn,David Casero,Holly Courtney,Antonio Gonzalez,Thomas G. Graeber,A. Brantley Hall,Kathleen Lake,Carol J. Landers,Himel Mallick,Himel Mallick,Damian R. Plichta,Mahadev Prasad,Gholamali Rahnavard,Gholamali Rahnavard,Jenny S. Sauk,Dmitry Shungin,Dmitry Shungin,Yoshiki Vázquez-Baeza,Richard A. White,Jonathan Braun,Lee A. Denson,Lee A. Denson,Janet K. Jansson,Rob Knight,Subra Kugathasan,Dermot P.B. McGovern,Joseph F. Petrosino,Thaddeus S. Stappenbeck,Harland S. Winter,Clary B. Clish,Eric A. Franzosa,Hera Vlamakis,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier,Curtis Huttenhower,Curtis Huttenhower +48 more
TL;DR: It is demonstrated that periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts, and integrative analysis identified microbial, biochemical, and host factors central to this dysregulation.
Journal ArticleDOI
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome
Melanie Schirmer,Melanie Schirmer,Eric A. Franzosa,Eric A. Franzosa,Jason Lloyd-Price,Jason Lloyd-Price,Lauren J. McIver,Lauren J. McIver,Randall Schwager,Tiffany W. Poon,Ashwin N. Ananthakrishnan,Elizabeth Andrews,Gildardo Barron,Kathleen Lake,Mahadev Prasad,Jenny Sauk,Jenny Sauk,Betsy W. Stevens,Robin G. Wilson,Jonathan Braun,Lee A. Denson,Subramaniam Kugathasan,Dermot P.B. McGovern,Hera Vlamakis,Ramnik J. Xavier,Curtis Huttenhower,Curtis Huttenhower +26 more
TL;DR: Analysis of paired metagenomes and metatranscriptomes associated with patients with inflammatory bowel disease (IBD) and non-IBD controls over time provides some insights into microbial community variation and potential pathways influencing IBD symptoms.
Journal ArticleDOI
In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores.
Jeffrey B. Schwimmer,Jeffrey B. Schwimmer,Joel E. Lavine,Laura Wilson,Brent A. Neuschwander-Tetri,Stavra A. Xanthakos,Rohit Kohli,Sarah Endicott Barlow,Miriam B. Vos,Saul J. Karpen,Jean P. Molleston,Peter F. Whitington,Philip J. Rosenthal,Ajay Jain,Karen F. Murray,Elizabeth M. Brunt,David E. Kleiner,Mark L. Van Natta,Jeanne M. Clark,James Tonascia,E. Doo,Stephanie H. Abrams,Sarah E. Barlow,Ryan Himes,Rajesh Krisnamurthy,Leanel Maldonado,Rory Mahabir,Kimberlee Bernstein,Kristin Bramlage,Kim M. Cecil,Stephanie DeVore,Kathleen Lake,Daniel J. Podberesky,Alexander J. Towbin,Stavra A. Xanthakos,Gerald Behr,Jay H. Lefkowitch,Ali A. Mencin,Elena Reynoso,Adina Alazraki,Rebecca Cleeton,Saul J. Karpen,Jessica Cruz Munos,Nicholas Raviele,Miriam B. Vos,Molly Bozic,Oscar W. Cummings,Ann Klipsch,Sarah Munson,Kumar Sandrasegaran,Girish Subbarao,Kimberly Kafka,Ann O. Scheimann,Katie Amsden,Mark Fishbein,Elizabeth Kirwan,Saeed Mohammad,Cynthia K. Rigsby,Lisa Sharda,Jose Derdoy,Ajay Jain,Debra King,Pat Osmack,Joan Siegner,Susan Stewart,Susan Torretta,Kristina Wriston,Susan S. Baker,Lixin Zhu,Jonathon Africa,Jorge E. Angeles,Sandra Arroyo,Hannah I. Awai,Cynthia Behling,Craig Bross,Janis Durelle,Michael S. Middleton,Kimberly P. Newton,Melissa Paiz,Jennifer Sanford,Claude B. Sirlin,Patricia Ugalde-Nicalo,Mariana Dominguez Villarreal,Bradley E. Aouizerat,Jesse Courtier,Linda D. Ferrell,Shannon Fleck,Ryan M. Gill,Camille Langlois,Emily R. Perito,Patrika Tsai,Kara Cooper,Simon Horslen,Evelyn K. Hsu,Karen F. Murray,Randolph K. Otto,Matthew M. Yeh,Melissa Young,Kathryn J. Fowler,Sherry Brown,Edward Doo,Jay H. Hoofnagle,Patricia R. Robuck,Averell H. Sherker,Rebecca Torrance,Patricia Belt,Michele Donithan,Erin Hallinan,Milana Isaacson,Kevin P. May,Laura Miriel,Alice L. Sternberg,Mark L. Van Natta,Ivana A. Vaughn,Laura A. Wilson,Katherine P. Yates +115 more
TL;DR: It is found that 1 year of CBDR did not reduce overall histologic markers of NAFLD compared with placebo in children, and those taking CBDR had a 4-fold better chance of histologic improvement.
Journal ArticleDOI
Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients with Crohn’s Disease
Lee A. Denson,Ingrid Jurickova,Rebekah Karns,Kelly A Shaw,David J. Cutler,David T. Okou,Anne Dodd,Kathryn Quinn,Kajari Mondal,Bruce J. Aronow,Yael Haberman,Aaron Linn,Adam Price,Ramona Bezold,Kathleen Lake,Kimberly Jackson,Thomas D. Walters,Anne M. Griffiths,Robert N. Baldassano,Joshua D. Noe,Jeffrey S. Hyams,Wallace Crandall,Barbara S. Kirschner,Melvin B. Heyman,Scott B. Snapper,Stephen L. Guthery,Marla Dubinsky,Neal S. Leleiko,Anthony R. Otley,Ramnik J. Xavier,Christine Stevens,Mark J. Daly,Michael E. Zwick,Subra Kugathasan +33 more
TL;DR: The authors identified missense mutations in genes that encode NADPH oxidases in children with CD that were associated with a more aggressive disease course and reduced ROS production by neutrophils from the patients.
Journal ArticleDOI
A Multidisciplinary Clinical Program is Effective in Stabilizing BMI and Reducing Transaminase Levels in Pediatric Patients with NAFLD
Stephanie DeVore,Rohit Kohli,Kathleen Lake,Lynda Nicholas,Kim Dietrich,William F. Balistreri,Stavra A. Xanthakos +6 more
TL;DR: A clinically feasible multidisciplinary program for obese pediatric patients with NAFLD stabilized BMI z score and significantly improved aminotransferase levels at 1-year follow-up is found.