Kim Lawson

TL;DR: In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers and within any stratum of observed LDL cholesterol, risk of CAD was higher among FH mutations carriers than non carriers.

TL;DR: Although the "Exome Array" was used to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals, none of these four variants was associated with risk for CHD, suggesting that examples of low- frequencies with robust effects on both lipids and CHD will be limited.

TL;DR: Aggregate analysis of mutation data revealed a significantly increased number of rare variants across 58 neuropathy-associated genes in subjects versus controls, suggesting that mutation burden potentially contributes to phenotypic variability.

TL;DR: Mexican Americans with NIDDM are experiencing premature and excessive mortality compared with the general population, and the results clearly link microvascular complications with macrovascular disease, but this link is not explained by a more untoward profile of traditional cardiovascular risk factors.

TL;DR: Despite the strong association with Lp(a) levels, the genetic basis of this association is investigated using a panel of up to 1447 ancestry informative markers, and no association of any LPA SNP with incident coronary heart disease is found.