D
Diego Ardissino
Researcher at University of Parma
Publications - 33
Citations - 12766
Diego Ardissino is an academic researcher from University of Parma. The author has contributed to research in topics: Myocardial infarction & Coronary artery disease. The author has an hindex of 18, co-authored 33 publications receiving 11103 citations.
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Journal ArticleDOI
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek,Konrad J. Karczewski,Konrad J. Karczewski,Eric Vallabh Minikel,Eric Vallabh Minikel,Kaitlin E. Samocha,Eric Banks,Timothy Fennell,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,James S. Ware,Andrew J. Hill,Andrew J. Hill,Andrew J. Hill,Beryl B. Cummings,Beryl B. Cummings,Taru Tukiainen,Taru Tukiainen,Daniel P. Birnbaum,Jack A. Kosmicki,Laramie E. Duncan,Laramie E. Duncan,Karol Estrada,Karol Estrada,Fengmei Zhao,Fengmei Zhao,James Zou,Emma Pierce-Hoffman,Emma Pierce-Hoffman,Joanne Berghout,David Neil Cooper,Nicole A. Deflaux,Mark A. DePristo,Ron Do,Jason Flannick,Jason Flannick,Menachem Fromer,Laura D. Gauthier,Jackie Goldstein,Jackie Goldstein,Namrata Gupta,Daniel P. Howrigan,Daniel P. Howrigan,Adam Kiezun,Mitja I. Kurki,Mitja I. Kurki,Ami Levy Moonshine,Pradeep Natarajan,Lorena Orozco,Gina M. Peloso,Gina M. Peloso,Ryan Poplin,Manuel A. Rivas,Valentin Ruano-Rubio,Samuel A. Rose,Douglas M. Ruderfer,Khalid Shakir,Peter D. Stenson,Christine Stevens,Brett Thomas,Brett Thomas,Grace Tiao,María Teresa Tusié-Luna,Ben Weisburd,Hong-Hee Won,Dongmei Yu,David Altshuler,David Altshuler,Diego Ardissino,Michael Boehnke,John Danesh,Stacey Donnelly,Roberto Elosua,Jose C. Florez,Jose C. Florez,Stacey Gabriel,Gad Getz,Gad Getz,Stephen J. Glatt,Christina M. Hultman,Sekar Kathiresan,Markku Laakso,Steven A. McCarroll,Steven A. McCarroll,Mark I. McCarthy,Mark I. McCarthy,Dermot P.B. McGovern,Ruth McPherson,Benjamin M. Neale,Benjamin M. Neale,Aarno Palotie,Shaun Purcell,Danish Saleheen,Jeremiah M. Scharf,Pamela Sklar,Patrick F. Sullivan,Patrick F. Sullivan,Jaakko Tuomilehto,Ming T. Tsuang,Hugh Watkins,Hugh Watkins,James G. Wilson,Mark J. Daly,Mark J. Daly,Daniel G. MacArthur,Daniel G. MacArthur +106 more
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Posted ContentDOI
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek,Konrad J. Karczewski,Eric Vallabh Minikel,Kaitlin E. Samocha,Eric Banks,Timothy Fennell,Anne H. O’Donnell-Luria,James S. Ware,Andrew J. Hill,Beryl B. Cummings,Taru Tukiainen,Daniel P. Birnbaum,Jack A. Kosmicki,Laramie E. Duncan,Karol Estrada,Fengmei Zhao,James Zou,Emma Pierce-Hoffman,David Neil Cooper,Mark A. DePristo,Ron Do,Jason Flannick,Menachem Fromer,Laura D. Gauthier,Jackie Goldstein,Namrata Gupta,Daniel P. Howrigan,Adam Kiezun,Mitja I. Kurki,Ami Levy Moonshine,Pradeep Natarajan,Lorena Orozco,Gina M. Peloso,Ryan Poplin,Manuel A. Rivas,Valentin Ruano-Rubio,Douglas M. Ruderfer,Khalid Shakir,Peter D. Stenson,Christine Stevens,Brett Thomas,Grace Tiao,María Teresa Tusié-Luna,Ben Weisburd,Hong-Hee Won,Dongmei Yu,David Altshuler,Diego Ardissino,Michael Boehnke,John Danesh,Roberto Elosua,Jose C. Florez,Stacey Gabriel,Gad Getz,Christina M. Hultman,Sekar Kathiresan,Markku Laakso,Steven A. McCarroll,Mark I. McCarthy,Dermot P.B. McGovern,Ruth McPherson,Benjamin M. Neale,Aarno Palotie,Shaun Purcell,Danish Saleheen,Jeremiah M. Scharf,Pamela Sklar,Patrick F. Sullivan,Jaakko Tuomilehto,Hugh Watkins,James G. Wilson,Mark J. Daly,Daniel G. MacArthur +72 more
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) sequence data for 60,706 individuals of diverse ethnicities generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Journal ArticleDOI
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
Amit Khera,Amit Khera,Hong-Hee Won,Gina M. Peloso,Gina M. Peloso,Kim Lawson,Traci M. Bartz,Xuan Deng,Elisabeth M. van Leeuwen,Pradeep Natarajan,Pradeep Natarajan,Connor A. Emdin,Alexander G. Bick,Alanna C. Morrison,Jennifer A. Brody,Namrata Gupta,Akihiro Nomura,Akihiro Nomura,Thorsten Kessler,Stefano Duga,Joshua C. Bis,Cornelia M. van Duijn,L. Adrienne Cupples,Bruce M. Psaty,Daniel J. Rader,John Danesh,Heribert Schunkert,Ruth McPherson,Martin Farrall,Hugh Watkins,Eric S. Lander,James G. Wilson,Adolfo Correa,Eric Boerwinkle,Piera Angelica Merlini,Diego Ardissino,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan +39 more
TL;DR: In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers and within any stratum of observed LDL cholesterol, risk of CAD was higher among FH mutations carriers than non carriers.
Journal ArticleDOI
Darapladib for preventing ischemic events in stable coronary heart disease.
Harvey D. White,Claes Held,Ralph A.H. Stewart,Elizabeth Tarka,Rebekkah Brown,Richard Davies,Andrzej Budaj,Robert A. Harrington,P. Gabriel Steg,P. Gabriel Steg,P. Gabriel Steg,Diego Ardissino,Paul W. Armstrong,Alvaro Avezum,Philip E. Aylward,Alfonso Bryce,Hong Chen,Ming Fong Chen,Ramón Corbalán,Anthony J. Dalby,Nicolas Danchin,Robbert J. de Winter,Stefan Denchev,Rafael Diaz,Moses Elisaf,Marcus Flather,Marcus Flather,Assen Goudev,Christopher B. Granger,Liliana Grinfeld,Judith S. Hochman,Steen Husted,Hyo-Soo Kim,Wolfgang Koenig,Aleš Linhart,Eva Lonn,Jose Lopez-Sendon,Athanasios J. Manolis,Emile R. Mohler,Jose C. Nicolau,Prem Pais,Alexander Parkhomenko,Terje R. Pedersen,Daniel Pella,Marco A. Ramos-Corrales,Mikhail Ruda,Mátyás Sereg,Saulat Siddique,Peter Sinnaeve,Peter K. Smith,Piyamitr Sritara,Henk P. Swart,Rody G. Sy,Tamio Teramoto,Hung-Fat Tse,David Watson,W. Douglas Weaver,Robert M. Weiss,Margus Viigimaa,Dragos Vinereanu,Jun-Ren Zhu,Christopher P. Cannon,Lars Wallentin +62 more
TL;DR: In patients with stable coronary heart disease, darapladib did not significantly reduce the risk of the primary composite end point of cardiovascular death, myocardial infarction, or stroke.
Journal ArticleDOI
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.
Connor A. Emdin,Amit Khera,Pradeep Natarajan,Derek Klarin,Hong-Hee Won,Gina M. Peloso,Nathan O. Stitziel,Akihiro Nomura,Seyedeh M. Zekavat,Alexander G. Bick,Namrata Gupta,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Cristen J. Willer,Gonçalo R. Abecasis,Janine F. Felix,Ramachandran S. Vasan,Eric S. Lander,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Danish Saleheen,Sekar Kathiresan +37 more
TL;DR: Beyond CHD, genetically lowered Lp(a) levels are associated with a lower risk of peripheral vascular disease, stroke, heart failure, and aortic stenosis, and no association with 31 other disorders, including type 2 diabetes and cancer.