K
Kristin G. Ardlie
Researcher at Broad Institute
Publications - 165
Citations - 90852
Kristin G. Ardlie is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 74, co-authored 142 publications receiving 76019 citations. Previous affiliations of Kristin G. Ardlie include Massachusetts Institute of Technology & Buck Institute for Research on Aging.
Papers
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Journal ArticleDOI
Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.
Guillaume Lettre,Guillaume Lettre,Johannah L. Butler,Johannah L. Butler,Kristin G. Ardlie,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn +7 more
TL;DR: The results indicate that common variation in these GH/IGF1 axis genes is not a major determinant of stature, and suggest that if common variation contributes to adult height variation in the general population, the variants are in other, possibly unanticipated genes.
Journal ArticleDOI
A vast resource of allelic expression data spanning human tissues
Stephane E. Castel,François Aguet,Pejman Mohammadi,Shankara Anand,Kristin G. Ardlie,Stacey Gabriel,Gad Getz,Aaron Graubert,Kane Hadley,Robert E. Handsaker,Katherine H. Huang,Seva Kashin,Xiao Li,Daniel G. MacArthur,Sam Meier,Jared L. Nedzel,Duyen T. Nguyen,Ayellet V. Segrè,Ellen Todres,Brunilda Balliu,Alvaro N. Barbeira,Alexis Battle,Rodrigo Bonazzola,Andrew Brown,Christopher D. Brown,Donald F. Conrad,Daniel J. Cotter,Nancy J. Cox,Sayantan Das,Olivia M. De Goede,Emmanouil T. Dermitzakis,Jonah Einson,Barbara E. Engelhardt,Eleazar Eskin,Tiffany Eulalio,Nicole M. Ferraro,Elise D. Flynn,Laure Fresard,Eric R. Gamazon,Diego Garrido-Martín,Michael J. Gloudemans,Roderic Guigó,Andrew R. Hame,Yuan He,Paul J. Hoffman,Farhad Hormozdiari,Lei Hou,Hae Kyung Im,Brian Jo,Silva Kasela,Manolis Kellis,Sarah Kim-Hellmuth,Alan Kwong,Tuuli Lappalainen,Xin Li,Yanyu Liang,Serghei Mangul,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Daniel Nachun,Andrew B. Nobel,Meritxell Oliva,YoSon Park,Yongjin Park,Princy Parsana,Abhiram Rao,Ferran Reverter,John M. Rouhana,Chiara Sabatti,Ashis Saha,Andrew D. Skol,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Nicole A. Teran,Ana Viñuela,Gao Wang,Xiaoquan Wen,Fred A. Wright,Valentin Wucher,Yuxin Zou,Pedro G. Ferreira,Gen Li,Marta Melé,Esti Yeger-Lotem,Mary Barcus,Debra Bradbury,Tanya Krubit,Jeffrey McLean,Liqun Qi,Karna Robinson,Nancy Roche,Anna M. Smith,Leslie H. Sobin,David Tabor,Anita H. Undale,Jason Bridge,Lori E. Brigham,Barbara A. Foster,Bryan Gillard,Richard Hasz,Marcus Hunter,Christopher Johns,Mark H. Johnson,Ellen Karasik,Gene Kopen,William F. Leinweber,Alisa McDonald,Michael T. Moser,Kevin Myer,Kimberley Ramsey,Brian Roe,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Joseph Wheeler,Scott D. Jewell,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Philip A. Branton,Laura Barker,Heather M. Gardiner,Maghboeba Mosavel,Laura A. Siminoff,Paul Flicek,Maximilian Haeussler,Thomas Juettemann,W. James Kent,Christopher Lee,Conner C. Powell,Kate R. Rosenbloom,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Nathan S. Abell,Joshua M. Akey,Lin Chen,Kathryn Demanelis,Jennifer A. Doherty,Andrew P. Feinberg,Kasper D. Hansen,Peter Hickey,Farzana Jasmine,Lihua Jiang,Rajinder Kaul,Muhammad G. Kibriya,Jin Billy Li,Qin Li,Shin Lin,Sandra Linder,Brandon L. Pierce,Lindsay F. Rizzardi,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Meng Wang,Latarsha J. Carithers,Ping Guan,Susan E. Koester,A. Roger Little,Helen M. Moore,Concepcion R. Nierras,Abhi Rao,Jimmie B. Vaught,Simona Volpi +170 more
TL;DR: A vast AE resource generated from the GTEx v8 release is presented and the utility of this resource is demonstrated, and an extension of the tool phASER is developed that allows effect sizes of cis -regulatory variants to be estimated using haplotype-level AE data.
Journal ArticleDOI
Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People
Jose C. Florez,Christina M. Agapakis,Noël P. Burtt,Maria Sun,Peter Almgren,Lennart Råstam,Tiinamaija Tuomi,Daniel Gaudet,Thomas J. Hudson,Mark J. Daly,Kristin G. Ardlie,Joel N. Hirschhorn,Leif Groop,David Altshuler +13 more
TL;DR: No statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes.
Posted Content
The Human Cell Atlas White Paper
Human Cell Atlas Meeting Participants,Aviv Regev,Sarah A. Teichmann,Orit Rozenblatt-Rosen,Michael J. T. Stubbington,Kristin G. Ardlie,Ido Amit,Paola Arlotta,Gary D. Bader,Christophe Benoist,Moshe Biton,Bernd Bodenmiller,Benoit Bruneau,Peter J. Campbell,Mary Carmichael,Piero Carninci,Leslie Castelo-Soccio,Menna R. Clatworthy,Hans Clevers,Christian Conrad,Roland Eils,Jeremy Freeman,Lars Fugger,Berthold Goettgens,Daniel B. Graham,Anna Greka,Nir Hacohen,Muzlifah Haniffa,Ingo Helbig,Robert O. Heuckeroth,Sekar Kathiresan,Seung K. Kim,Allon Klein,Bartha Maria Knoppers,Arnold R. Kriegstein,Eric S. Lander,Jane Lee,Ed S. Lein,Sten Linnarsson,Evan Macosko,Sonya A. MacParland,Robert Majovski,Partha P. Majumder,John C. Marioni,Ian D. McGilvray,Miriam Merad,Musa M. Mhlanga,Shalin H. Naik,Martijn C. Nawijn,Garry P. Nolan,Benedict Paten +50 more
TL;DR: The Human Cell Atlas will be made up of comprehensive reference maps of all human cells as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating disease, and will help scientists understand how genetic variants impact disease risk, define drug toxicities, discover better therapies, and advance regenerative medicine.
Journal ArticleDOI
Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.
Michael J. Gloudemans,Margaret L. Antonio,Nathan S. Abell,Brunilda Balliu,YoSon Park,Alicia R. Martin,Shaila Musharoff,Abhiram Rao,François Aguet,Alvaro N. Barbeira,Rodrigo Bonazzola,Farhad Hormozdiari,Farhad Hormozdiari,Kristin G. Ardlie,Christopher D. Brown,Hae Kyung Im,Tuuli Lappalainen,Xiaoquan Wen,Stephen B. Montgomery +18 more
TL;DR: A local ancestry map for admixed individuals in the GTEx v8 release is provided and the impact of ancestry and admixture on gene expression, eQTLs, and GWAS colocalization is described.