K
Kristin G. Ardlie
Researcher at Broad Institute
Publications - 165
Citations - 90852
Kristin G. Ardlie is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 74, co-authored 142 publications receiving 76019 citations. Previous affiliations of Kristin G. Ardlie include Massachusetts Institute of Technology & Buck Institute for Research on Aging.
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Journal ArticleDOI
Demonstrating stratification in a European American population.
Catarina D. Campbell,Elizabeth L. Ogburn,Kathryn L. Lunetta,Helen N. Lyon,Helen N. Lyon,Matthew L. Freedman,Matthew L. Freedman,Leif Groop,David Altshuler,David Altshuler,Kristin G. Ardlie,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn +13 more
TL;DR: The failure of standard methods to detect stratification in case-control association studies indicates that new methods may be required, and a SNP in the gene LCT that varies widely in frequency across Europe was strongly associated with height.
Journal ArticleDOI
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Zari Dastani,Hivert M-F.,Hivert M-F.,N J Timpson,Perry Jrb.,Perry Jrb.,Xin Yuan,Robert A. Scott,Peter Henneman,Iris M. Heid,Jorge R. Kizer,Lyytikäinen L-P.,Christian Fuchsberger,Toshiko Tanaka,Toshiko Tanaka,Andrew P. Morris,Kerrin S. Small,Kerrin S. Small,Aaron Isaacs,Marian Beekman,Stefan Coassin,Kurt Lohman,Lu Qi,Stavroula Kanoni,Stavroula Kanoni,James S. Pankow,Uh H-W.,Ying Wu,Aurelian Bidulescu,Laura J. Rasmussen-Torvik,Greenwood Cmt.,Martin Ladouceur,Jonna L. Grimsby,Alisa K. Manning,Liu C-T.,Jaspal S. Kooner,Vincent Mooser,Peter Vollenweider,Karen Kapur,John C. Chambers,Nicholas J. Wareham,Claudia Langenberg,Rune R. Frants,K Willems-Vandijk,Ben A. Oostra,Sara M. Willems,Claudia Lamina,Thomas W. Winkler,Bruce M. Psaty,Bruce M. Psaty,Russel Tracy,Jennifer A. Brody,I Chen,J. Viikari,Mika Kähönen,Peter P. Pramstaller,David M. Evans,B. St Pourcain,Naveed Sattar,Andrew R. Wood,Stefania Bandinelli,Olga D. Carlson,Josephine M. Egan,Stefan Böhringer,D. van Heemst,Lyudmyla Kedenko,Kati Kristiansson,Nuotio M-L.,Loo B-M.,T.B. Harris,Melissa Garcia,Alka M. Kanaya,Margot Haun,Norman Klopp,Wichmann H-E.,Panos Deloukas,Panos Deloukas,E Katsareli,David Couper,Bruce Bartholow Duncan,Bruce Bartholow Duncan,M. Kloppenburg,Linda S. Adair,Judith B. Borja,James G. Wilson,Solomon K. Musani,Xiuqing Guo,Toby Johnson,Toby Johnson,Toby Johnson,Robert K. Semple,Tanya M. Teslovich,Tanya M. Teslovich,Matthew A. Allison,Susan Redline,Sarah G. Buxbaum,Karen L. Mohlke,Ingrid Meulenbelt,Christie M. Ballantyne,George Dedoussis,Frank B. Hu,Yongmei Liu,Bernhard Paulweber,Tim D. Spector,P E Slagboom,Luigi Ferrucci,Antti Jula,Markus Perola,Olli T. Raitakari,Jose C. Florez,Jose C. Florez,Jose C. Florez,Veikko Salomaa,Johan G. Eriksson,Timothy M. Frayling,Andrew A. Hicks,Terho Lehtimäki,George Davey Smith,David S. Siscovick,Florian Kronenberg,C.M. van Duijn,C.M. van Duijn,Loos Rjf.,Loos Rjf.,Dawn M. Waterworth,James B. Meigs,Josée Dupuis,Josée Dupuis,J B Richards,Benjamin F. Voight,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,G Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Steven A. McCarroll,Oliver Hofmann,Ayellet V. Segrè,Ayellet V. Segrè,M. van Hoek,M. van Hoek,Pau Navarro,Kristin G. Ardlie,Beverley Balkau,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,K B Boström,Bert Bravenboer,S Bumpstead,N P Burtt,Guillaume Charpentier,P S Chines,Marilyn C. Cornelis,G Crawford,G Crawford,Doney Asf.,Katherine S. Elliott,A L Elliott,Michael R. Erdos,Caroline S. Fox,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Johnson Prv.,Torben Jørgensen,Kao Whl.,Augustine Kong,Peter Kraft,Johanna Kuusisto,T. Lauritzen,M Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,Petersen A-K.,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,Nigel W. Rayner,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Richa Saxena,B M Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,A J Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,R. M. van Dam,T.W. van Haeften,T van Herpt,J. V. van Vliet-Ostaptchouk,G B Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Torben Hansen,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,A D Morris,Palmer Cna.,Palmer Cna.,Igor Rudan,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln D. Stein,Jaakko Tuomilehto,A Uitterlinden,Mark Walker,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Inês Barroso,L Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,J.F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,C M van Duijn,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Nicole Soranzo,Nicole Soranzo,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Reedik Mägi,Joshua C. Randall,Paul Elliott,Paul Elliott,Denis Rybin,Abbas Dehghan,Jouke-Jan Hottenga,Kijoung Song,Anuj Goel,Taina K. Lajunen,Alex S. F. Doney,Christine Cavalcanti-Proença,Meena Kumari,N J Timpson,Carina Zabena,Erik Ingelsson,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,A Elliott,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Yavuz Ariyurek,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Sven Bergmann,Sven Bergmann,Murielle Bochud,Amélie Bonnefond,Knut Borch-Johnsen,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,S J Bumpstead,Chen Y-Di.,P Chines,Robert Clarke,Coin Ljm.,Mark E. Cooper,Laura Crisponi,Day Inm.,de Geus Ejc.,Jérôme Delplanque,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Scott M. Grundy,R. Gwilliam,Göran Hallmans,Naomi Hammond,Xijing Han,Hartikainen A-L.,Caroline Hayward,S C Heath,Serge Hercberg,David R. Hillman,Aroon D. Hingorani,Jennie Hui,Joseph Hung,Joseph Hung,Marika Kaakinen,Jaakko Kaprio,Jaakko Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,K O Kyvik,G M Lathrop,Debbie A Lawlor,O Le Bacquer,Cécile Lecoeur,Yun Li,Robert W. Mahley,Massimo Mangino,María Teresa Martínez-Larrad,Jarred B. McAteer,Jarred B. McAteer,Ruth McPherson,Christa Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,Sutapa Mukherjee,Silvia Naitza,Matt Neville,Marco Orrù,Ruth E. Pakyz,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,J F Peden,Nancy L. Pedersen,Pfeiffer Afh.,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,A Pouta,M. A. Province,Kenneth Rice,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Olov Rolandsson,A. Sandbaek,M Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Udo Seedorf,Stephen J. Sharp,B Shields,Gunnar Sigurðsson,Sijbrands Ejg.,Sijbrands Ejg.,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Nicholas L. Smith,Ulla Sovio,A Swift,Holly E. Syddall,Syvänen A-C.,Anke Tönjes,A G Uitterlinden,K W van Dijk,K W van Dijk,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,N Vogelzangs,N Vogelzangs,Gerard Waeber,P J Wagner,P J Wagner,P J Wagner,Andrew Walley,Kim L. Ward,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,Witteman Jcm.,Yarnell Jwg.,Diana Zelenika,Björn Zethelius,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M C Zillikens,M C Zillikens,Ingrid B. Borecki,Pierre Meneton,Magnusson Pke.,David M. Nathan,Gordon H. Williams,Kaisa Silander,Kaisa Silander,Stefan R. Bornstein,Peter Schwarz,Jochen Spranger,Fredrik Karpe,Alan R. Shuldiner,Cyrus Cooper,Manuel Serrano-Ríos,Lars Lind,Lyle J. Palmer,Lyle J. Palmer,Paul W. Franks,Shah Ebrahim,Michael Marmot,Alan F. Wright,Michael Stumvoll,Anders Hamsten,Anders Hamsten,Thomas A. Buchanan,Timo T. Valle,Jerome I. Rotter,Penninx Bwjh.,Penninx Bwjh.,Dorret I. Boomsma,Dorret I. Boomsma,Anyuan Cao,Angelo Scuteri,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin M-R.,Leena Peltonen,V Mooser,Kiran Musunuru,Kiran Musunuru,Albert V. Smith,Andrew C. Edmondson,Ioannis M. Stylianou,Masahiro Koseki,James P. Pirruccello,James P. Pirruccello,James P. Pirruccello,Daniel I. Chasman,Christopher T. Johansen,Sigrid W. Fouchier,Gina M. Peloso,Gina M. Peloso,Maja Barbalić,Sally L. Ricketts,J. C. Bis,Mary F. Feitosa,Marju Orho-Melander,Olle Melander,Xiaohui Li,Yoon Shin Cho,Min Jin Go,Young-Jin Kim,Lee J-Y.,Taesung Park,K Kim,Xueling Sim,Ong Rt-H.,Damien C. Croteau-Chonka,Leslie A. Lange,Josh Smith,Andreas Ziegler,Weihua Zhang,Zee Ryl.,John Whitfield,John R. Thompson,Ida Surakka,Ida Surakka,J.H. Smit,Juha Sinisalo,Jan Scott,Juha Saharinen,Chiara Sabatti,Lynda M. Rose,Robert Roberts,Mark J. Rieder,Alex N. Parker,Guillaume Paré,Christopher J. O'Donnell,Christopher J. O'Donnell,Markku S. Nieminen,Deborah A. Nickerson,Grant W. Montgomery,Wendy L. McArdle,David Masson,Nicholas G. Martin,Fabio Marroni,Gavin Lucas,Robert Luben,Lokki M-L.,Guillaume Lettre,Lenore J. Launer,Edward G. Lakatta,Reijo Laaksonen,Inke R. König,Khaw K-T.,Lee M. Kaplan,Åsa Johansson,Janssens Acjw.,Wilmar Igl,G K Hovingh,Christian Hengstenberg,Aki S. Havulinna,Aki S. Havulinna,Nicholas D. Hastie,T B Harris,Talin Haritunians,Alyson Hall,L C Groop,Elena Gonzalez,Nelson B. Freimer,Jeanette Erdmann,Kenechi Ejebe,Angela Döring,Anna F. Dominiczak,Serkalem Demissie,Serkalem Demissie,U de Faire,Mark J. Caulfield,S.M. Boekholdt,Themistocles L. Assimes,Thomas Quertermous,Mark Seielstad,Tien Yin Wong,Tai E-S.,Alan B. Feranil,Christopher W. Kuzawa,Herman A. Taylor,S. Gabriel,Hilma Holm,Vilmundur Gudnason,Ronald M. Krauss,Jose M. Ordovas,Jose M. Ordovas,Patricia B. Munroe,J S Kooner,Alan R. Tall,Robert A. Hegele,Kastelein Jjp.,Eric E. Schadt,David P. Strachan,Muredach P. Reilly,Nilesh J. Samani,Heribert Schunkert,L A Cupples,M S Sandhu,Paul M. Ridker,Daniel J. Rader,Sekar Kathiresan +618 more
TL;DR: A meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease identifies novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
Journal ArticleDOI
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse.
Kerstin Lindblad-Toh,Ellen Winchester,Mark J. Daly,David G. Wang,David G. Wang,Joel N. Hirschhorn,Joel N. Hirschhorn,Jean-Philippe Laviolette,Kristin G. Ardlie,David Reich,Elizabeth M. Robinson,Pamela Sklar,Pamela Sklar,Nila Shah,Daryl J. Thomas,Jian-Bing Fan,Thomas R. Gingeras,Janet A. Warrington,Nila Patil,Thomas J. Hudson,Thomas J. Hudson,Eric S. Lander +21 more
TL;DR: A large-scale analysis of SNPs in the mouse genome and identifies a collection of 2,848 SNPs located in 1,755 sequence-tagged sites (STSs) using high-density oligonucleotide arrays, providing a first-generation SNP map of the mouse.
Journal ArticleDOI
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
A. L. Williams Amy,A. L. Williams Amy,S. B R Jacobs Suzanne,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,Claire Churchhouse,Carla Marquez-Luna,María José Gómez-Vázquez,N. P. Burtt Noël,Carlos A. Aguilar-Salinas,Clicerio Gonzalez-Villalpando,Jose C. Florez,Jose C. Florez,Lorena Orozco,Teresa Tusié-Luna,David Altshuler,David Altshuler,David Altshuler,Stephan Ripke,Stephan Ripke,Alisa K. Manning,Humberto García-Ortiz,Benjamin M. Neale,Benjamin M. Neale,David Reich,David Reich,Daniel O. Stram,Juan Carlos Fernández-López,Sandra Romero-Hidalgo,Nick Patterson,Christopher A. Haiman,Irma Aguilar-Delfín,Angélica Martínez-Hernández,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Eunice Rodríguez-Arellano,Xavier Soberón,J. C. Florez Jose,J. C. Florez Jose,M. A. González-Villalpando María Elena,Brian E. Henderson,Kristine R. Monroe,Lynne R. Wilkens,Laurence N. Kolonel,Loic Le Marchand,Laura Riba,M. A. Ordóñez-Sánchez María Luisa,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Robert C. Onofrio,Wendy Brodeur,Diane Gage,Jacquelyn Murphy,Jennifer Franklin,Scott Mahan,Kristin G. Ardlie,Andrew Crenshaw,Wendy Winckler,Kay Prüfer,Michael V. Shunkov,Susanna Sawyer,Udo Stenzel,Janet Kelso,Monkol Lek,Monkol Lek,Sriram Sankararaman,Sriram Sankararaman,Daniel G. MacArthur,Daniel G. MacArthur,A.P. Derevianko,Svante Pääbo,Suzanne B.R. Jacobs,Shuba Gopal,James A. Grammatikos,Ian Smith,Kevin Bullock,Amy Deik,Amanda Souza,Kerry A. Pierce,Clary B. Clish,Timothy Fennell,Yossi Farjoun,Stacey Gabriel,Myron D. Gross,Mark A. Pereira,Mark Seielstad,Woon-Puay Koh,E. Shyong Tai,Jason Flannick,Jason Flannick,Pierre Fontanillas,Andrew D. Morris,Tanya M. Teslovich,Gil Atzmon,John Blangero,Donald W. Bowden,John C. Chambers,John C. Chambers,Yoon Shin Cho,Ravindranath Duggirala,Benjamin Glaser,Benjamin Glaser,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Jong-Young Lee,Yik Ying Teo,Yik Ying Teo,James G. Wilson,Sobha Puppala,Vidya S. Farook,Farook Thameem,Hanna E. Abboud,Ralph A. DeFronzo,Christopher P. Jenkinson,Donna M. Lehman,Joanne E. Curran,Maria L. Cortes,C. González-Villalpando Clicerio,L. Orozco Lorena +128 more
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Journal ArticleDOI
Cell type–specific genetic regulation of gene expression across human tissues
Sarah Kim-Hellmuth,Sarah Kim-Hellmuth,François Aguet,Meritxell Oliva,Manuel Muñoz-Aguirre,Silva Kasela,Valentin Wucher,Stephane E. Castel,Andrew R. Hamel,Andrew R. Hamel,Ana Viñuela,Amy L. Roberts,Serghei Mangul,Serghei Mangul,Xiaoquan Wen,Gao Wang,Alvaro N. Barbeira,Diego Garrido-Martín,Brian B. Nadel,Yuxin Zou,Rodrigo Bonazzola,Jie Quan,Andrew A. Brown,Andrew A. Brown,Angel Martinez-Perez,José Manuel Soria,Gad Getz,Gad Getz,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Kerrin S. Small,Matthew Stephens,Hualin S. Xi,Hae Kyung Im,Roderic Guigó,Ayellet V. Segrè,Ayellet V. Segrè,Barbara E. Stranger,Barbara E. Stranger,Kristin G. Ardlie,Tuuli Lappalainen +40 more
TL;DR: A growing number of in silico cell type deconvolution methods and associated reference panels with cell type–specific marker genes enable the robust estimation of the enrichment of specific cell types from bulk tissue gene expression data.