L
Laura L. Kilarski
Researcher at St George's, University of London
Publications - 16
Citations - 1060
Laura L. Kilarski is an academic researcher from St George's, University of London. The author has contributed to research in topics: Genome-wide association study & Missing heritability problem. The author has an hindex of 13, co-authored 15 publications receiving 875 citations. Previous affiliations of Laura L. Kilarski include University of Cologne & Cardiff University.
Papers
More filters
Journal ArticleDOI
Differential effects of severe vs mild GBA mutations on Parkinson disease
Ziv Gan-Or,Idan Amshalom,Laura L. Kilarski,Anat Bar-Shira,Mali Gana-Weisz,Anat Mirelman,Karen Marder,Susan B. Bressman,Nir Giladi,Avi Orr-Urtreger +9 more
TL;DR: Mild and severe heterozygous GBA mutations differentially affect the risk and the AAO of Parkinson disease, and the results have important implications for genetic counseling and clinical follow-up.
Journal ArticleDOI
Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease
Margaux F. Keller,Mohamad Saad,Mohamad Saad,Jose Bras,F Bettella,Nayia Nicolaou,Javier Simón-Sánchez,Florian Mittag,Finja Büchel,Manu Sharma,Manu Sharma,J. R. Gibbs,J. R. Gibbs,Claudia Schulte,Claudia Schulte,Valentina Moskvina,Alexandra Durr,Peter Holmans,Laura L. Kilarski,Rita Guerreiro,Dena G. Hernandez,Dena G. Hernandez,Alexis Brice,Pauli Ylikotila,Hreinn Stefansson,Kari Majamaa,Huw R. Morris,Nigel Williams,T. Gasser,T. Gasser,Peter Heutink,Nicholas W. Wood,John Hardy,Maria Martinez,Maria Martinez,AB Singleton,Mike A. Nalls +36 more
TL;DR: The results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered.
Journal ArticleDOI
Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease
Laura L. Kilarski,J. P. Pearson,Victoria Elizabeth Newsway,Elisa Majounie,M. Duleeka W Knipe,Anjum Misbahuddin,Patrick F. Chinnery,David J. Burn,Carl E Clarke,Marie-Helene Marion,Alistair J. Lewthwaite,Alistair J. Lewthwaite,David Nicholl,David Nicholl,Nicholas W. Wood,Karen E. Morrison,Caroline H. Williams-Gray,Jonathan R. Evans,Stephen Sawcer,Roger A. Barker,M M Wickremaratchi,Yoav Ben-Shlomo,Nigel Williams,Huw R. Morris +23 more
TL;DR: This study screened 136 EOPD probands from a high‐ascertainment regional and community‐based prevalence study for pathogenic mutations in PARK2 (parkin), PINK1, PARK7 (DJ‐1), and exon 41 of LRRK2 and shows an increased likelihood of mutations in patients with lower AAO, family history, or parental consanguinity.
Journal ArticleDOI
Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis.
TL;DR: Assessment of the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis found that for most of the substances, the available data is not yet sufficient or inconclusive.
Journal ArticleDOI
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12
Laura L. Kilarski,Sefanja Achterberg,William J. Devan,William J. Devan,Matthew Traylor,Rainer Malik,Arne Lindgren,Guillame Pare,Pankaj Sharma,Agniesczka Slowik,Vincent Thijs,Matthew Walters,Bradford B. Worrall,Michèle M. Sale,Ale Algra,L. Jaap Kappelle,Cisca Wijmenga,Bo Norrving,Johanna K. Sandling,Lars Rönnblom,An Goris,Andre Franke,Cathie Sudlow,Peter M. Rothwell,Christopher Levi,Elizabeth G. Holliday,Myriam Fornage,Bruce M. Psaty,Bruce M. Psaty,Solveig Gretarsdottir,Unnar Thorsteinsdottir,Unnar Thorsteinsdottir,Sudha Seshadri,Braxton D. Mitchell,Steven J. Kittner,Steven J. Kittner,Robert Clarke,Jemma C. Hopewell,Joshua C. Bis,Giorgio B. Boncoraglio,James F. Meschia,M. Arfan Ikram,Björn M. Hansen,Joan Montaner,Gudmar Thorleifsson,Kari Stefanson,Jonathan Rosand,Jonathan Rosand,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Martin Farrall,Martin Dichgans,Hugh S. Markus,Steve Bevan +54 more
TL;DR: A novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07–1.13], p = 7.12 × 10−11) was identified with ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes.