F
Florian Mittag
Researcher at University of Tübingen
Publications - 20
Citations - 1059
Florian Mittag is an academic researcher from University of Tübingen. The author has contributed to research in topics: SBML & BioModels Database. The author has an hindex of 13, co-authored 19 publications receiving 884 citations. Previous affiliations of Florian Mittag include Heidelberg University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease
Margaux F. Keller,Mohamad Saad,Mohamad Saad,Jose Bras,F Bettella,Nayia Nicolaou,Javier Simón-Sánchez,Florian Mittag,Finja Büchel,Manu Sharma,Manu Sharma,J. R. Gibbs,J. R. Gibbs,Claudia Schulte,Claudia Schulte,Valentina Moskvina,Alexandra Durr,Peter Holmans,Laura L. Kilarski,Rita Guerreiro,Dena G. Hernandez,Dena G. Hernandez,Alexis Brice,Pauli Ylikotila,Hreinn Stefansson,Kari Majamaa,Huw R. Morris,Nigel Williams,T. Gasser,T. Gasser,Peter Heutink,Nicholas W. Wood,John Hardy,Maria Martinez,Maria Martinez,AB Singleton,Mike A. Nalls +36 more
TL;DR: The results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered.
Journal ArticleDOI
SBML Level 3: an extensible format for the exchange and reuse of biological models
Sarah M. Keating,Sarah M. Keating,Dagmar Waltemath,Matthias König,Fengkai Zhang,Andreas Dräger,Claudine Chaouiya,Claudine Chaouiya,Frank Bergmann,Andrew Finney,Colin S. Gillespie,Tomáš Helikar,Stefan Hoops,Rahuman S Malik-Sheriff,Stuart L. Moodie,Ion I. Moraru,Chris J. Myers,Aurélien Naldi,Brett G. Olivier,Brett G. Olivier,Brett G. Olivier,Sven Sahle,James C. Schaff,Lucian P. Smith,Lucian P. Smith,Maciej J. Swat,Denis Thieffry,Leandro Watanabe,Darren J. Wilkinson,Darren J. Wilkinson,Michael L. Blinov,Kimberly Begley,James R. Faeder,Harold F. Gómez,Thomas M. Hamm,Yuichiro Inagaki,Wolfram Liebermeister,Allyson L. Lister,Daniel Lucio,Eric Mjolsness,Carole J. Proctor,Karthik Raman,Nicolas Rodriguez,Clifford A. Shaffer,Bruce E. Shapiro,Joerg Stelling,Neil Swainston,Naoki Tanimura,John Wagner,Martin Meier-Schellersheim,Herbert M. Sauro,Bernhard O. Palsson,Hamid Bolouri,Hiroaki Kitano,Akira Funahashi,Henning Hermjakob,John Doyle,Michael Hucka,Richard R. Adams,Nicholas Alexander Allen,Bastian R. Angermann,Marco Antoniotti,Gary D. Bader,Jan Červený,Mélanie Courtot,Christopher Cox,Piero Dalle Pezze,Emek Demir,William S. Denney,Harish Dharuri,Julien Dorier,Dirk Drasdo,Ali Ebrahim,Johannes Eichner,Johan Elf,Lukas Endler,Chris T. Evelo,Christoph Flamm,Ronan M. T. Fleming,Martina Fröhlich,Mihai Glont,Emanuel Gonçalves,Martin Golebiewski,Hovakim Grabski,Alex Gutteridge,Damon Hachmeister,Leonard A. Harris,Benjamin D. Heavner,Ron Henkel,William S. Hlavacek,Bin Hu,Daniel R. Hyduke,Hidde de Jong,Nick Juty,Peter D. Karp,Jonathan R. Karr,Douglas B. Kell,Roland Keller,Ilya Kiselev,Steffen Klamt,Edda Klipp,Christian Knüpfer,Fedor A. Kolpakov,Falko Krause,Martina Kutmon,Camille Laibe,Conor Lawless,Lu Li,Leslie M. Loew,Rainer Machné,Yukiko Matsuoka,Pedro Mendes,Huaiyu Mi,Florian Mittag,Pedro T. Monteiro,Kedar Nath Natarajan,Poul M. F. Nielsen,Tramy Nguyen,Alida Palmisano,Jean-Baptiste Pettit,Thomas Pfau,Robert Phair,Tomas Radivoyevitch,Johann M. Rohwer,Oliver A. Ruebenacker,Julio Saez-Rodriguez,Martin Scharm,Henning Schmidt,Falk Schreiber,Michael Schubert,Roman Schulte,Stuart C. Sealfon,Kieran Smallbone,Sylvain Soliman,Melanie I. Stefan,Devin P. Sullivan,Koichi Takahashi,Bas Teusink,David Tolnay,Ibrahim Vazirabad,Axel von Kamp,Ulrike Wittig,Clemens Wrzodek,Finja Wrzodek,Ioannis Xenarios,Anna Zhukova,Jeremy Zucker +146 more
TL;DR: The latest edition of the Systems Biology Markup Language (SBML) is reviewed, a format designed for this purpose that leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models.
Journal ArticleDOI
Path2Models: large-scale generation of computational models from biochemical pathway maps
Finja Büchel,Finja Büchel,Nicolas Rodriguez,Nicolas Rodriguez,Neil Swainston,Clemens Wrzodek,Tobias Czauderna,Roland Keller,Florian Mittag,Florian Mittag,Michael Schubert,Mihai Glont,Martin Golebiewski,Martijn P. van Iersel,Sarah M. Keating,Matthias Rall,Michael Wybrow,Henning Hermjakob,Michael Hucka,Douglas B. Kell,Wolfgang Müller,Pedro Mendes,Pedro Mendes,Andreas Zell,Claudine Chaouiya,Julio Saez-Rodriguez,Falk Schreiber,Falk Schreiber,Camille Laibe,Andreas Dräger,Andreas Dräger,Nicolas Le Novère,Nicolas Le Novère +32 more
TL;DR: The Path2Models project has automatically generated mathematical models from pathway representations using a suite of freely available software, resulting in more than 140 000 freely available models.
Journal ArticleDOI
Large-scale generation of computational models from biochemical pathway maps
Finja Büchel,Nicolas Rodriguez,Neil Swainston,Clemens Wrzodek,Tobias Czauderna,Roland Keller,Florian Mittag,Michael Schubert,Mihai Glont,Martin Golebiewski,Martijn P. van Iersel,Sarah M. Keating,Matthias Rall,Michael Wybrow,Henning Hermjakob,Michael Hucka,Douglas B. Kell,Wolfgang Müller,Pedro Mendes,Andreas Zell,Claudine Chaouiya,Julio Saez-Rodriguez,Falk Schreiber,Camille Laibe,Andreas Dräger,Nicolas Le Novère +25 more
TL;DR: The BioModels Database as mentioned in this paper is a suite of freely available software for automatically generating mathematical models from pathway representations using SBML Core and Qual packages, which can accelerate the development of mathematical models by providing initial starting points ready for parametrization.
Journal ArticleDOI
A pathway based analysis provides additional support for an immune related genetic susceptibility to Parkinson's disease
Peter Holmans,Valentina Moskvina,Lesley Jones,Manu Sharma,Manu Sharma,Alexey Vedernikov,Finja Büchel,Mohamad Saad,Jose Bras,F Bettella,Nayia Nicolaou,Javier Simón-Sánchez,Florian Mittag,J. Raphael Gibbs,Claudia Schulte,Claudia Schulte,Alexandra Durr,Alexandra Durr,Alexandra Durr,Rita Guerreiro,Dena G. Hernandez,Alexis Brice,Hreinn Stefansson,Kari Majamaa,Thomas Gasser,Thomas Gasser,Peter Heutink,Nicholas W. Wood,Maria Martinez,Andrew B. Singleton,Mike A. Nalls,John Hardy,Huw R. Morris,Nigel Williams +33 more
TL;DR: In this paper, a pathway-based analysis was applied to identify biological functions that were significantly enriched for genes containing variants associated with Parkinson's disease, and two independent GWA studies were identified that both had a significant excess in the number of functional categories enriched for PD-associated genes.