M
Margaux F. Keller
Researcher at National Institutes of Health
Publications - 35
Citations - 4702
Margaux F. Keller is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 28, co-authored 35 publications receiving 3832 citations. Previous affiliations of Margaux F. Keller include University of Cambridge & Merck & Co..
Papers
More filters
Journal ArticleDOI
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls,Nathan Pankratz,Christina M. Lill,Chuong B. Do,Dena G. Hernandez,Dena G. Hernandez,Mohamad Saad,Mohamad Saad,Mohamad Saad,Anita L. DeStefano,Anita L. DeStefano,Eleanna Kara,Jose Bras,Manu Sharma,Claudia Schulte,Margaux F. Keller,Sampath Arepalli,Christopher Letson,Connor Edsall,Hreinn Stefansson,Xinmin Liu,Hannah A. Pliner,Joseph H. Lee,Rong Cheng,M. Arfan Ikram,John P. A. Ioannidis,Georgios M. Hadjigeorgiou,Joshua C. Bis,Maria Martinez,Maria Martinez,Joel S. Perlmutter,Alison Goate,Karen Marder,Brian K. Fiske,Margaret Sutherland,Georgia Xiromerisiou,Richard H. Myers,Lorraine N. Clark,Kari Stefansson,John Hardy,Peter Heutink,Honglei Chen,Nicholas W. Wood,Henry Houlden,Haydeh Payami,Alexis Brice,Alexis Brice,William K. Scott,Thomas Gasser,Lars Bertram,Nicholas Eriksson,Tatiana Foroud,Andrew B. Singleton +52 more
TL;DR: This article conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls.
Journal ArticleDOI
A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
Mike A. Nalls,Raquel Duran,Grisel Lopez,Marzena Kurzawa-Akanbi,Ian G. McKeith,Patrick F. Chinnery,Christopher Morris,Jessie Theuns,Jessie Theuns,David Crosiers,David Crosiers,Patrick Cras,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,David M. A. Mann,Julie S. Snowden,Stuart Pickering-Brown,Nicola Halliwell,Yvonne S Davidson,Linda Gibbons,Jenny Harris,Una-Marie Sheerin,Jose Bras,John Hardy,Lorraine N. Clark,Karen Marder,Lawrence S. Honig,Daniela Berg,Walter Maetzler,Kathrin Brockmann,Thomas Gasser,Fabiana Novellino,Aldo Quattrone,Grazia Annesi,Elvira Valeria De Marco,Ekaterina Rogaeva,Mario Masellis,Mario Masellis,Sandra E. Black,Sandra E. Black,Juan M. Bilbao,Tatiana Foroud,Bernardino Ghetti,William C. Nichols,Nathan Pankratz,Glenda M. Halliday,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Stephan Klebe,Alexandra Durr,Charles Duyckaerts,Charles Duyckaerts,Charles Duyckaerts,Alexis Brice,Benoit I. Giasson,John Q. Trojanowski,Howard I. Hurtig,Nahid Tayebi,Claudia Landazabal,Claudia Landazabal,Melanie A. Knight,Margaux F. Keller,Margaux F. Keller,Andrew B. Singleton,Tyra G. Wolfsberg,Ellen Sidransky +68 more
TL;DR: In this paper, the authors found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88).
Journal ArticleDOI
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Felix R. Day,Katherine S. Ruth,Deborah J. Thompson,Kathryn L. Lunetta,Natalia Pervjakova,Daniel I. Chasman,Lisette Stolk,Hilary K. Finucane,Patrick Sulem,Brendan Bulik-Sullivan,Tõnu Esko,Andrew D. Johnson,Cathy E. Elks,Nora Franceschini,Chunyan He,Elisabeth Altmaier,Jennifer A. Brody,Lude Franke,Jennifer E. Huffman,Margaux F. Keller,Patrick F. McArdle,Teresa Nutile,Eleonora Porcu,Antonietta Robino,Lynda M. Rose,Ursula M. Schick,Jennifer A. Smith,Alexander Teumer,Michela Traglia,Dragana Vuckovic,Jie Yao,Wei Zhao,Eva Albrecht,Najaf Amin,Tanguy Corre,Jouke-Jan Hottenga,Massimo Mangino,Albert V. Smith,Toshiko Tanaka,Goncąlo R. Abecasis,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Volker Arndt,Alice M. Arnold,Caterina Barbieri,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Leslie Bernstein,Suzette J. Bielinski,Carl Blomqvist,Eric Boerwinkle,Natalia Bogdanova,S.E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Thibaud Boutin,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Archie Campbell,Harry Campbell,Stephen J. Chanock,J. Ross Chapman,Yii-Der Ida Chen,Georgia Chenevix-Trench,Fergus J. Couch,Andrea D. Coviello,Angela Cox,Kamila Czene,Hatef Darabi,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Alison M. Dunning,John D. Eicher,P. A. Fasching,Jessica D. Faul,Jonine D. Figueroa,Dieter Flesch-Janys,Ilaria Gandin,Melissa E. Garcia,Montserrat Garcia-Closas,Graham G. Giles,Giorgia Girotto,Mark S. Goldberg,Anna González-Neira,Mark O. Goodarzi,Megan L. Grove,D. F. Gudbjartsson,Pascal Guenel,Xiuqing Guo,Christopher A. Haiman,Per Hall,U Hamann,Brian E. Henderson,Lynne J. Hocking,Albert Hofman,Georg Homuth,Maartje J. Hooning,John L. Hopper,Frank B. Hu,Jinyan Huang,Keith Humphreys,David J. Hunter,Anna Jakubowska,Samuel E. Jones,Maria Kabisch,David Karasik,Julia A. Knight,Ivana Kolcic,Charles Kooperberg,Veli-Matti Kosma,Jennifer Kriebel,Vessela N. Kristensen,Diether Lambrechts,Claudia Langenberg,Jingmei Li,Xin Li,Sara Lindström,Yongmei Liu,Jian'an Luan,Jan Lubinski,Reedik Mägi,Arto Mannermaa,Judith Manz,Sara Margolin,Jonathan Marten,Nicholas G. Martin,Corrado Masciullo,A. Meindl,Kyriaki Michailidou,E. Mihailov,Lili Milani,Roger L. Milne,Martina Müller-Nurasyid,Mike A. Nalls,Benjamin M. Neale,Benjamin M. Neale,Heli Nevanlinna,Patrick Neven,Anne B. Newman,Børge G. Nordestgaard,Janet E. Olson,Sandosh Padmanabhan,Paolo Peterlongo,Ulrike Peters,Astrid Petersmann,Julian Peto,Paul D.P. Pharoah,Nicola Pirastu,Ailith Pirie,Giorgio Pistis,Ozren Polasek,David J. Porteous,Bruce M. Psaty,Katri Pylkäs,Paolo Radice,Leslie J. Raffel,Fernando Rivadeneira,Igor Rudan,Anja Rudolph,Daniela Ruggiero,Cinzia Sala,Serena Sanna,Elinor J. Sawyer,David Schlessinger,Marjanka K. Schmidt,Frank Schmidt,Rita K. Schmutzler,Minouk J. Schoemaker,Robert A. Scott,Caroline Seynaeve,Jacques Simard,Rossella Sorice,Melissa C. Southey,Doris Stöckl,Konstantin Strauch,Anthony J. Swerdlow,Kent D. Taylor,Unnur Thorsteinsdottir,Amanda E. Toland,Ian Tomlinson,Thérèse Truong,Laufey Tryggvadottir,Stephen Turner,Diego Vozzi,Qin Wang,Melissa Wellons,Gonneke Willemsen,James F. Wilson,Robert Winqvist,Bruce H. R. Wolffenbuttel,A. F. Wright,Drakoulis Yannoukakos,Tatijana Zemunik,Wei Zheng,Marek Zygmunt,Sven Bergmann,Dorret I. Boomsma,Julie E. Buring,Luigi Ferrucci,Grant W. Montgomery,Vilmundur Gudnason,Tim D. Spector,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Marina Ciullo,Laura Crisponi,Douglas F. Easton,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Caroline Hayward,Sharon L.R. Kardia,Peter Kraft,Barbara McKnight,Andres Metspalu,Alanna C. Morrison,Alexander P. Reiner,Paul M. Ridker,Jerome I. Rotter,Daniela Toniolo,André G. Uitterlinden,Sheila Ulivi,Henry Völzke,Nicholas J. Wareham,David R. Weir,Laura M. Yerges-Armstrong,Alkes L. Price,Kari Stefansson,Jenny A. Visser,Ken K. Ong,Jenny Chang-Claude,Joanne M. Murabito,John R. B. Perry,Anna Murray +241 more
TL;DR: A dual strategy to identify common and low-frequency protein-coding variation associated with age at natural menopause and enrichment of signals in or near genes involved in delayed puberty are reported, highlighting the first molecular links between the onset and end of reproductive lifespan.
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
Mike A. Nalls,Nathan Pankratz,Christina M. Lill,Chuong B. Do,Dena G. Hernandez,Dena G. Hernandez,Mohamad Saad,Mohamad Saad,Mohamad Saad,Anita L. DeStefano,Anita L. DeStefano,Eleanna Kara,Jose Bras,Manu Sharma,Claudia Schulte,Margaux F. Keller,Sampath Arepalli,Christopher Letson,Connor Edsall,Hreinn Stefansson,Xinmin Liu,Hannah A. Pliner,Joseph H. Lee,Rong Cheng,M. Arfan Ikram,John P. A. Ioannidis,Georgios M. Hadjigeorgiou,Joshua C. Bis,Maria Martinez,Maria Martinez,Joel S. Perlmutter,Alison Goate,Karen Marder,Brian K. Fiske,Margaret Sutherland,Georgia Xiromerisiou,Richard H. Myers,Lorraine N. Clark,Kari Stefansson,John Hardy,Peter Heutink,Honglei Chen,Nicholas W. Wood,Henry Houlden,Haydeh Payami,Alexis Brice,Alexis Brice,William K. Scott,Thomas Gasser,Lars Bertram,Nicholas Eriksson,Tatiana Foroud,Andrew B. Singleton +52 more
TL;DR: A meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants found four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant.
Journal ArticleDOI
Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease
Margaux F. Keller,Mohamad Saad,Mohamad Saad,Jose Bras,F Bettella,Nayia Nicolaou,Javier Simón-Sánchez,Florian Mittag,Finja Büchel,Manu Sharma,Manu Sharma,J. R. Gibbs,J. R. Gibbs,Claudia Schulte,Claudia Schulte,Valentina Moskvina,Alexandra Durr,Peter Holmans,Laura L. Kilarski,Rita Guerreiro,Dena G. Hernandez,Dena G. Hernandez,Alexis Brice,Pauli Ylikotila,Hreinn Stefansson,Kari Majamaa,Huw R. Morris,Nigel Williams,T. Gasser,T. Gasser,Peter Heutink,Nicholas W. Wood,John Hardy,Maria Martinez,Maria Martinez,AB Singleton,Mike A. Nalls +36 more
TL;DR: The results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered.