M
Maggie C.Y. Ng
Researcher at Vanderbilt University Medical Center
Publications - 17
Citations - 2042
Maggie C.Y. Ng is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Type 2 diabetes & Genome-wide association study. The author has an hindex of 9, co-authored 17 publications receiving 1160 citations. Previous affiliations of Maggie C.Y. Ng include The Chinese University of Hong Kong & University of Illinois at Chicago.
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Journal ArticleDOI
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Anubha Mahajan,Daniel Taliun,Matthias Thurner,Neil R. Robertson,Jason M. Torres,N. William Rayner,N. William Rayner,Anthony Payne,Valgerdur Steinthorsdottir,Robert A. Scott,Niels Grarup,James P. Cook,Ellen M. Schmidt,Matthias Wuttke,Chloé Sarnowski,Reedik Mägi,Jana Nano,Christian Gieger,Stella Trompet,Cécile Lecoeur,Michael Preuss,Bram P. Prins,Xiuqing Guo,Lawrence F. Bielak,Jennifer E. Below,Donald W. Bowden,John C. Chambers,Young-Jin Kim,Maggie C.Y. Ng,Lauren E. Petty,Xueling Sim,Weihua Zhang,Weihua Zhang,Amanda J. Bennett,Jette Bork-Jensen,Chad M. Brummett,Mickaël Canouil,Kai-Uwe Ec Kardt,Krista Fischer,Sharon L.R. Kardia,Florian Kronenberg,Kristi Läll,Ching-Ti Liu,Adam E. Locke,Jian'an Luan,Ioanna Ntalla,Vibe Nylander,Sebastian Schönherr,Claudia Schurmann,Loic Yengo,Erwin P. Bottinger,Ivan Brandslund,Cramer Christensen,George Dedoussis,Jose C. Florez,Ian Ford,Oscar H. Franco,Timothy M. Frayling,Vilmantas Giedraitis,Sophie Hackinger,Andrew T. Hattersley,Christian Herder,M. Arfan Ikram,Martin Ingelsson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Jennifer Kriebel,Johanna Kuusisto,Symen Ligthart,Cecilia M. Lindgren,Cecilia M. Lindgren,Allan Linneberg,Allan Linneberg,Valeriya Lyssenko,Valeriya Lyssenko,Vasiliki Mamakou,Thomas Meitinger,Karen L. Mohlke,Andrew D. Morris,Andrew D. Morris,Girish N. Nadkarni,James S. Pankow,Annette Peters,Naveed Sattar,Alena Stančáková,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Jaakko Tuomilehto,Daniel R. Witte,Josée Dupuis,Patricia A. Peyser,Eleftheria Zeggini,Ruth J. F. Loos,Philippe Froguel,Philippe Froguel,Erik Ingelsson,Erik Ingelsson,Lars Lind,Leif Groop,Leif Groop,Markku Laakso,Francis S. Collins,J. Wouter Jukema,Colin N. A. Palmer,Harald Grallert,Andres Metspalu,Abbas Dehghan,Abbas Dehghan,Anna Köttgen,Gonçalo R. Abecasis,James B. Meigs,Jerome I. Rotter,Jonathan Marchini,Oluf Pedersen,Torben Hansen,Torben Hansen,Claudia Langenberg,Nicholas J. Wareham,Kari Stefansson,Kari Stefansson,Anna L. Gloyn,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,Mark I. McCarthy +131 more
TL;DR: Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight.
Journal ArticleDOI
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Cassandra N. Spracklen,Cassandra N. Spracklen,Momoko Horikoshi,Young Jin Kim,Kuang Lin,Fiona Bragg,Sanghoon Moon,Ken Suzuki,Claudia H. T. Tam,Yasuharu Tabara,Soo Heon Kwak,Fumihiko Takeuchi,Jirong Long,Victor Jun Yu Lim,Jin-Fang Chai,Chien-Hsiun Chen,Masahiro Nakatochi,Jie Yao,Jie Yao,Hyeok Sun Choi,Apoorva K Iyengar,Hannah J Perrin,Sarah M Brotman,Martijn van de Bunt,Anna L. Gloyn,Jennifer E. Below,Jennifer E. Below,Michael Boehnke,Donald W. Bowden,John C. Chambers,Anubha Mahajan,Anubha Mahajan,Mark I. McCarthy,Maggie C.Y. Ng,Maggie C.Y. Ng,Lauren E. Petty,Lauren E. Petty,Weihua Zhang,Weihua Zhang,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Linda S. Adair,Masato Akiyama,Zheng Bian,Juliana C.N. Chan,Li-Ching Chang,Miao-Li Chee,Yii-Der Ida Chen,Yii-Der Ida Chen,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Shufa Du,Penny Gordon-Larsen,Myron D. Gross,Xiuqing Guo,Xiuqing Guo,Yu Guo,Sohee Han,Annie-Green Howard,Wei Huang,Yi-Jen Hung,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Chii-Min Hwu,Sahoko Ichihara,Masato Isono,Hye-Mi Jang,Guozhi Jiang,Jost B. Jonas,Yoichiro Kamatani,Tomohiro Katsuya,Takahisa Kawaguchi,Chiea Chuen Khor,Chiea Chuen Khor,Katsuhiko Kohara,Myung-Shik Lee,Myung-Shik Lee,Nanette R. Lee,Liming Li,Jianjun Liu,Jianjun Liu,Andrea O.Y. Luk,Jun Lv,Yukinori Okada,Mark A Pereira,Charumathi Sabanayagam,Shi Jinxiu,Dong Mun Shin,Wing-Yee So,Atsushi Takahashi,Brian Tomlinson,Brian Tomlinson,Fuu Jen Tsai,Rob M. van Dam,Yong-Bing Xiang,Ken Yamamoto,Toshimasa Yamauchi,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Liang Zhang,Wei Zheng,Michiya Igase,Yoon Shin Cho,Jerome I. Rotter,Jerome I. Rotter,Ya Xing Wang,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Mitsuhiro Yokota,Jer-Yuarn Wu,Ching-Yu Cheng,Tien Yin Wong,Xiao-Ou Shu,Norihiro Kato,Kyong-Soo Park,Kyong-Soo Park,Kyong-Soo Park,E-Shyong Tai,Fumihiko Matsuda,Woon-Puay Koh,Ronald Cw Ma,Shiro Maeda,Iona Y Millwood,Ju Young Lee,Takashi Kadowaki,Robin G. Walters,Bong-Jo Kim,Karen L. Mohlke,Xueling Sim +132 more
TL;DR: A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2abetes in both East Asian and European populations.
Posted ContentDOI
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Cassandra N. Spracklen,Momoko Horikoshi,Young Jin Kim,Kuang Lin,Fiona Bragg,Sanghoon Moon,Ken Suzuki,Claudia H. T. Tam,Yasuharu Tabara,Soo Heon Kwak,Fumihiko Takeuchi,Jirong Long,Victor Jun Yu Lim,Jin-Fang Chai,Chien-Hsiun Chen,Masahiro Nakatochi,Jie Yao,Hyeok Sun Choi,Apoorva K Iyengar,Hannah J Perrin,Sarah M Brotman,Martijn van de Bunt,Anna L. Gloyn,Jennifer E. Below,Michael Boehnke,Donald W. Bowden,John C. Chambers,Anubha Mahajan,Mark I. McCarthy,Maggie C.Y. Ng,Lauren E. Petty,Weihua Zhang,Andrew P. Morris,Linda S. Adair,Zheng Bian,Juliana C.N. Chan,Li-Ching Chang,Miao-Li Chee,Yii-Der Ida Chen,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Shufa Du,Penny Gordon-Larsen,Myron D. Gross,Xiuqing Guo,Yu Guo,Sohee Han,Annie-Green Howard,Wei Huang,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Sahoko Ichihara,Masato Isono,Hye-Mi Jang,Guozhi Jiang,Jost B. Jonas,Yoichiro Kamatani,Tomohiro Katsuya,Takahisa Kawaguchi,Chiea Chuen Khor,Katsuhiko Kohara,Myung-Shik Lee,Nanette R. Lee,Liming Li,Jianjun Liu,Andrea O.Y. Luk,Jun Lv,Yukinori Okada,Mark A Pereira,Charumathi Sabanayagam,Shi Jinxiu,Dong Mun Shin,Wing-Yee So,Atsushi Takahashi,Brian Tomlinson,Fuu Jen Tsai,Rob M. van Dam,Yong-Bing Xiang,Ken Yamamoto,Toshimasa Yamauchi,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Liang Zhang,Wei Zheng,Michiya Igase,Yoon Shin Cho,Jerome I. Rotter,Ya Xing Wang,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Mitsuhiro Yokota,Jer-Yuarn Wu,Ching-Yu Cheng,Tien Yin Wong,Xiao-Ou Shu,Norihiro Kato,Kyong-Soo Park,E-Shyong Tai,Fumihiko Matsuda,Woon-Puay Koh,Ronald Cw Ma,Shiro Maeda,Iona Y Millwood,Ju Young Lee,Takashi Kadowaki,Robin G. Walters,Bong-Jo Kim,Karen L. Mohlke,Xueling Sim +111 more
TL;DR: The largest meta-analysis of East Asian individuals to identify new genetic associations and provide insight into T2D pathogenesis is performed.
Journal ArticleDOI
New complexities in the genetics of stuttering: significant sex-specific linkage signals
Rathi Suresh,Nicoline Grinager Ambrose,Cheryl A. Roe,Anna Pluzhnikov,Jacqueline K. Wittke-Thompson,Maggie C.Y. Ng,Xiaolin Wu,Edwin H. Cook,Cecilia Lundstrom,Marie Garsten,Ruth Ezrati,Ehud Yairi,Nancy J. Cox +12 more
TL;DR: The hypothesis that the genetic component to stuttering has significant sex effects is supported, based on linkage studies in 100 families of European descent ascertained in the United States, Sweden, and Israel.
Posted ContentDOI
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Anubha Mahajan,Cassandra N. Spracklen,Weihua Zhang,Maggie C.Y. Ng,Lauren E. Petty,Kitajima H,Yu Gz,S. Rüeger,Leo Speidel,Young-Jin Kim,Momoko Horikoshi,Josep M. Mercader,Daniel Taliun,Sanghoon Moon,Soo Heon Kwak,Neil R. Robertson,Nigel W. Rayner,Loh M,Bong-Jo Kim,Joshua Chiou,Irene Miguel-Escalada,Briotta Parolo Pd,Kuang Lin,Fiona Bragg,Preuss Mh,Fumihiko Takeuchi,Jana Nano,Xiuqing Guo,Lamri A,Masahiro Nakatochi,Robert A. Scott,Jin-Moo Lee,Alicia Huerta-Chagoya,Misa Graff,Jin-Fang Chai,Esteban J. Parra,Jie Yao,L.F. Bielak,Yasuharu Tabara,Yang Hai,Steinthorsdottir,James P. Cook,Mart Kals,Niels Grarup,Ellen M. Schmidt,Pan I,Tamar Sofer,Matthias Wuttke,Chloé Sarnowski,C Gieger,Darryl Nousome,Stella Trompet,Jirong Long,Sun M,Tong L,Wei Chen,Ahmad M,Raymond Noordam,Lim Vj,Claudia H. T. Tam,Yoonjung Yoonie Joo,Chao-Jung Chen,Laura M. Raffield,Cécile Lecoeur,Nisa M. Maruthur,Bram P. Prins,Aude Nicolas,Lisa R. Yanek,Guanjie Chen,Richard A. Jensen,Salman M. Tajuddin,Edmond K. Kabagambe,Ping An,Anny H. Xiang,Choi Hs,Brian E. Cade,Jingyi Tan,Abaitua F,Linda S. Adair,Adebowale Adeyemo,Carlos A. Aguilar-Salinas,Masato Akiyama,Sonia S. Anand,Alain G. Bertoni,Bian Z,Jette Bork-Jensen,Ivan Brandslund,Jennifer A. Brody,Chad M. Brummett,Thomas A. Buchanan,Mickaël Canouil,Juliana C.N. Chan,Li-Ching Chang,Miao-Li Chee,Chen J,Chen S,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Mary Cushman,Swapan K Das,de Silva Hj,George Dedoussis,Latchezar Dimitrov,Ayo P. Doumatey,Shufa Du,Qing Duan,Kai-Uwe Eckardt,Leslie S. Emery,Daniel S. Evans,Michelle K. Evans,Krista Fischer,James S. Floyd,Ian Ford,Myriam Fornage,Oscar H. Franco,Timothy M. Frayling,Barry I. Freedman,Christian Fuchsberger,Pauline Genter,Hertzel C. Gerstein,Giedraitis,Clicerio González-Villalpando,María Elena González-Villalpando,Mark O. Goodarzi,Penny Gordon-Larsen,David U. Gorkin,Myron D. Gross,Yuming Guo,Sophie Hackinger,Sohee Han,Andrew T. Hattersley,C. Herder,Annie-Green Howard,Willa A. Hsueh,Huang M,Wei Huang,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Sahoko Ichihara,Mohammad Arfan Ikram,Martin Ingelsson,Islam Mt,Motohide Isono,Jang H,Jasmine F,Jiang G,Jost B. Jonas,Marit E. Jørgensen,Torben Jørgensen,Yoichiro Kamatani,Kandeel Fr,Anuradhani Kasturiratne,Tomohiro Katsuya,Kaur,Takahisa Kawaguchi,Jacob M. Keaton,Abel N. Kho,Chiea Chuen Khor,Kibriya Mg,Donghee Kim,Kohara K,Jennifer Kriebel,Florian Kronenberg,Johanna Kuusisto,Kristi Läll,Leslie A. Lange,Lee M,Nanette R. Lee,Aaron Leong,Lin Li,Yun Li,Ruifang Li-Gao,Symen Ligthart,C M Lindgren,Allan Linneberg,Ching-Ti Liu,Jiang Liu,Adam E. Locke,Tin Louie,Jian'an Luan,Luk Ao,Luo X,Jun Lv,Lyssenko,Mamakou,K. R. Mani,Meitinger T,A. Metspalu,Andrew D. Morris,Girish N. Nadkarni,Jerry L. Nadler,Mike A. Nalls,Uma Nayak,Ioanna Ntalla,Yukinori Okada,Lorena Orozco,Patel,Mark A. Pereira,Annette Peters,Pirie Fj,Bianca Porneala,Gauri Prasad,Sebastian Preissl,Laura J. Rasmussen-Torvik,Alexander P. Reiner,Michael Roden,Rebecca Rohde,Kathryn Roll,Charumathi Sabanayagam,Maike Sander,Kevin Sandow,Naveed Sattar,Sebastian Schönherr,Claudia Schurmann,Shahriar M,Shi Jinxiu,Shin Dm,Daniel Shriner,Jennifer A. Smith,Wing-Yee So,Alena Stančáková,Adrienne M. Stilp,Konstantin Strauch,Suzuki K,Atsushi Takahashi,Kent D. Taylor,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Brian Tomlinson,Jason M. Torres,Tsai F,J. Tuomilehto,Teresa Tusié-Luna,Miriam S. Udler,Adan Valladares-Salgado,van Dam Rm,van Klinken Jb,Varma R,Marijana Vujkovic,Niels Wacher-Rodarte,Eleanor Wheeler,Eric A. Whitsel,Anand +245 more
TL;DR: Improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying foundations for functional investigations.