Jana Felicitas Schulz

TL;DR: This work analyzes the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation, and shows extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner.

TL;DR: A community-led effort involving Ensembl/ GENCODE, the HUGO Gene Nomenclature Committee (HGNC), UniProtKB, HUPO/ HPP and PeptideAtlas to produce a standardized catalog of 7,264 human Ribo-seq ORFs is outlined, outlining a path to bring protein-level evidence for Ribo’s ORFs into reference annotation databases; and a roadmap to facilitate research in the global community.

TL;DR: Using a human embryonic stem cell (hESC)-based pancreatic differentiation system, it is shown that many lncRNAs in direct vicinity of lineage-determining transcription factors (TFs) are dynamically regulated, predominantly cytosolic, and highly translated.

TL;DR: In this paper, the authors outline the initial stages of a community-led effort supported by GENCODE/Ensembl, HGNC and UniProt to produce a consolidated catalog of human Ribo-seq ORFs.

TL;DR: This paper analyzed the evolutionary origins of 7,264 recently cataloged human short open reading frames (sORFs) and found that most were evolutionarily young and had emerged de novo.