L
Lenard M. Voortman
Researcher at Leiden University Medical Center
Publications - 3
Citations - 51
Lenard M. Voortman is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Importin & Somatic cell. The author has an hindex of 2, co-authored 3 publications receiving 11 citations.
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Journal ArticleDOI
REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology.
Ugis Sarkans,Wah Chiu,Lucy M. Collinson,Michele C. Darrow,Jan Ellenberg,David Grunwald,Jean-Karim Hériché,Andrii Iudin,Gabriel G. Martins,Terry Meehan,Kedar Narayan,Ardan Patwardhan,Matthew R. G. Russell,Helen R. Saibil,Caterina Strambio-De-Castillia,Jason R. Swedlow,Christian Tischer,Virginie Uhlmann,Paul Verkade,Mary Barlow,Omer Ali Bayraktar,Ewan Birney,Cesare Catavitello,Christopher Cawthorne,Stephan Wagner-Conrad,Elizabeth Duke,Perrine Paul-Gilloteaux,Emmanuel Gustin,Maria Harkiolaki,Pasi Kankaanpää,Thomas Lemberger,Jo McEntyre,Josh Moore,Andrew W. Nicholls,Shuichi Onami,Helen Parkinson,Maddy Parsons,M. Romanchikova,Nicholas James Sofroniew,Jim Swoger,Nadine Utz,Lenard M. Voortman,Frances Wong,Peijun Zhang,Gerard J. Kleywegt,Alvis Brazma +45 more
TL;DR: In this paper, the authors propose metadata guidelines to address the needs of diverse communities within light and electron microscopy within microscopy, and the proposed Recommended Metadata for Biological Images (REMBI) will stimulate discussions about their implementation and future extension.
Journal ArticleDOI
Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis
Menno Spits,Lennert Janssen,Lenard M. Voortman,Raymond Kooij,Anna C. M. Neefjes,Huib Ovaa,Jacques Neefjes +6 more
TL;DR: Using a molecular GFP ladder, it is shown that in early mitosis, condensed chromatin excludes cytosolic proteins and nuclear proteins, including the proteasome, are then re-imported by conditional nuclear import mechanisms.
Journal ArticleDOI
Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis
Paul Geraeds Kemps,Timo C. Zondag,Eline C. Steenwijk,Quirine Andriessen,Jelske Borst,Sandra A. Vloemans,Dave L. Roelen,Lenard M. Voortman,Robert M. Verdijk,Carel J. M. van Noesel,Arjen H.G. Cleven,Cynthia Hawkins,Veronica Lang,Arnoud H. de Ru,George M.C. Janssen,Geert W. Haasnoot,Kees L. M. C. Franken,Ronald van Eijk,Nienke Solleveld-Westerink,Tom van Wezel,R. Maarten Egeler,R. Maarten Egeler,Auke Beishuizen,Jan A M van Laar,Oussama Abla,Cor van den Bos,Peter A. van Veelen,Astrid G. S. van Halteren +27 more
TL;DR: Questions are raised about the efficacy of immune checkpoint inhibitor therapy in LCH after it was found that the in silico predicted HLA class I binding and proteasome-generated neopeptides derived from the BRAFV600E protein are not presented by HLAclass I molecules.