Terry Meehan

TL;DR: The benefits and challenges of applying the ARRIVE guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres, are described.

TL;DR: In this paper, the authors propose metadata guidelines to address the needs of diverse communities within light and electron microscopy within microscopy, and the proposed Recommended Metadata for Biological Images (REMBI) will stimulate discussions about their implementation and future extension.

TL;DR: This study has established a systematic phenotype analysis approach that can be used to uncover the mechanism of circadian entrainment in mice and developed a machine learning algorithm to quantify these two parameters in the misalignment screen (SyncScreener) with existing datasets.

TL;DR: By all accounts, President Obama's Precision Medicine Initiative (PMI) promising molecular-guided diagnostics, therapeutics, and prevention strategies is eliciting enthusiasm and excitement among clinicians, translational researchers, and patients.

TL;DR: The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.