Jaroslav Sterba

TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.

TL;DR: GFI1 and GFI1B are identified as prominent medulloblastoma oncogenes and ‘enhancer hijacking’ is implicate as an efficient mechanism driving oncogene activation in a childhood cancer.

TL;DR: Targeted therapy is unlikely to be effective in the absence of the target, therefore the results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.

TL;DR: A re-evaluation of the long-term implications of intensified craniospinal irradiation in children with small residual portions of medulloblastoma is suggested as the marked benefit of EOR in the overall cohort was greatly attenuated after including molecular subgroup in the multivariable analysis.

TL;DR: The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy.