L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
Papers
More filters
Journal ArticleDOI
Ex vivo gene transfer and correction for cell-based therapies
TL;DR: This Review highlights the latest developments and the crucial challenges for cell-based therapies, with an emphasis on haematopoietic stem cell gene therapy, which is taken as a representative example given its advanced clinical translation.
Journal ArticleDOI
Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy.
Elisa Vigna,Luigi Naldini +1 more
TL;DR: The state of the art of lentiviral vector systems is reviewed, discussing their potential for gene therapy and their ability of transgene expression into target cells.
Journal ArticleDOI
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial
Maria Sessa,Laura Lorioli,Francesca Fumagalli,Serena Acquati,Daniela Redaelli,Cristina Baldoli,Sabrina Canale,Ignazio Diego Lopez,Francesco Morena,Andrea Calabria,Rossana Fiori,Paolo Silvani,Paola M.V. Rancoita,Michela Gabaldo,Fabrizio Benedicenti,Gigliola Antonioli,Andrea Assanelli,Maria Pia Cicalese,Ubaldo Del Carro,Maria Grazia Natali Sora,Sabata Martino,Angelo Quattrini,Eugenio Montini,Clelia Di Serio,Fabio Ciceri,Maria Grazia Roncarolo,Alessandro Aiuti,Luigi Naldini,Alessandra Biffi +28 more
TL;DR: The authors' ad-hoc findings provide preliminary evidence of safety and therapeutic benefit of HSC-GT, which resulted in protection from CNS demyelination in eight patients and, in at least three patients, amelioration of peripheral nervous system abnormalities, with signs of remyelinated at both sites.
Journal ArticleDOI
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
Angelo Amabile,Alessandro Migliara,Paola Capasso,Mauro Biffi,Davide Cittaro,Luigi Naldini,Angelo Lombardo +6 more
TL;DR: The endogenous retroviruses’ silencing machinery of embryonic stem cells is repurposed to stably silence three highly expressed genes in somatic cells by epigenetics, ensuring long-term memory of the repressive epigenetic state.
Journal ArticleDOI
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
Ferdinando Pucci,Mary Anna Venneri,Daniela Biziato,Alessandro Nonis,Davide Moi,Antonio Sica,Clelia Di Serio,Luigi Naldini,Michele De Palma +8 more
TL;DR: Tie2(+) embryonic/fetal macrophages, resident blood monocytes, and tumor-infiltrating TEMs represent distinct developmental stages of a TEM lineage committed to execute physiologic proangiogenic and tissue-remodeling programs, which can be co-opted by tumors.